Sex-dependent body weight changes after iontophoretic application of kainic acid into the LH or VMH

L. Lénárd, P. Sándor, A. Hajnal, G. Jandó, Z. Karádi, Y. Kai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Body weight changes and food and water intakes were studied in CFY male and female rats after kainic acid (KA)-induced destruction of the lateral hypothalamic area (LH) or the ventromedial hypothalamic nucleus (VMH). To minimize the extent of damages, KA was iontophoretically applied by means of glass micropipettes. KA was ejected in 50 or 80 mM concentrations with 5-15 μA current for 5 min. Tip diameter of pipettes varied between 10-20 μ.m. Lesions were restricted to the LH or VMH. Effects were sex-dependent. LH lesions resulted in hypophagia, hypodipsia and body weight loss only in male rats. On the other hand, only female animals exhibited hyperphagia and weight increase when the VMH was destroyed. The role of sex-dependence in hypothalamic body weight regulation is discussed.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalBrain Research Bulletin
Volume26
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Ventromedial Hypothalamic Nucleus
Lateral Hypothalamic Area
Body Weight Changes
Kainic Acid
Body Weight
Hyperphagia
Drinking
Glass
Weight Loss
Eating
Weights and Measures

Keywords

  • Feeding
  • Kainate iontophoresis
  • Lateral hypothalamus
  • Sex-dependent body weight
  • Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sex-dependent body weight changes after iontophoretic application of kainic acid into the LH or VMH. / Lénárd, L.; Sándor, P.; Hajnal, A.; Jandó, G.; Karádi, Z.; Kai, Y.

In: Brain Research Bulletin, Vol. 26, No. 1, 1991, p. 141-148.

Research output: Contribution to journalArticle

Lénárd, L. ; Sándor, P. ; Hajnal, A. ; Jandó, G. ; Karádi, Z. ; Kai, Y. / Sex-dependent body weight changes after iontophoretic application of kainic acid into the LH or VMH. In: Brain Research Bulletin. 1991 ; Vol. 26, No. 1. pp. 141-148.
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