Background: Clostridium perfringens septicemia with massive hemolysis is well known. The infection-induced acute hemolytic attack frequently occurs in chronic corpuscular hemolytic anemia. Alterations in mental status are common in septic patients. Case Report: The case of a 39-year-old woman with a history of chronic corpuscular hemolytic anemia experiencing weakness, pallor, and somnolence is presented. Hypothermia and an acute paranoid psychotic episode subsequently developed in the hospital. C. perfringens sepsis was detected from blood cultures. The patient was cured by penicillin and clindamycin. Her symptoms disappeared and there was total resolution of toxic encephalopathy according to brain MRI after six weeks. Conclusions: This report discusses a possible explanation for the origin of clostridial sepsis the role of brain MRI in sepsis-induced organic psychosyndromes, and underlines the need to obtain blood cultures in hypothermia suggestive of sepsis.
|Journal||Medical Science Monitor|
|Publication status||Published - Mar 1 2008|
- Alpha toxin
- Clostridium perfringens
- Hemolytic anemia
ASJC Scopus subject areas