Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome

M. Mohás, Nóra Szigeti, Lajos Markó, Gerg A. Molnár, Judit Cseh, Boglárka Laczy, Mónika Tamaskó, J. Balla, J. Kappelmayer, L. Wágner, Zoltán Wagner, Botond Csiky, J. Nagy, I. Wittmann

Research output: Contribution to journalArticle

Abstract

Background/Aims: Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. Methods: In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). Results: Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p <0.001) and correlated with serum total protein (r = -0.549, p <0.001), serum albumin (r = -0.596, p <0.001), proteinuria (r = 0.456, p <0.001) and serum total cholesterol (r = 0.523, p <0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p <0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p <0.001), serum albumin (r = -0.615, p <0.001), proteinuria (r = 0.694, p <0.001), and serum total cholesterol (r = 0.723, p <0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2. Conclusions: These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalKidney and Blood Pressure Research
Volume31
Issue number1
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Nephrotic Syndrome
Isoenzymes
Serum
Proteinuria
Blood Proteins
Serum Albumin
Cholesterol
Hypoproteinemia
Hypoalbuminemia
lactate dehydrogenase 2
Linear Models
Edema
Cross-Sectional Studies
Regression Analysis
Kidney

Keywords

  • Lactate dehydrogenase
  • Lactate dehydrogenase isozymes
  • Nephrotic syndrome
  • Renal damage

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Cardiology and Cardiovascular Medicine

Cite this

Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome. / Mohás, M.; Szigeti, Nóra; Markó, Lajos; Molnár, Gerg A.; Cseh, Judit; Laczy, Boglárka; Tamaskó, Mónika; Balla, J.; Kappelmayer, J.; Wágner, L.; Wagner, Zoltán; Csiky, Botond; Nagy, J.; Wittmann, I.

In: Kidney and Blood Pressure Research, Vol. 31, No. 1, 02.2008, p. 47-54.

Research output: Contribution to journalArticle

Mohás, M. ; Szigeti, Nóra ; Markó, Lajos ; Molnár, Gerg A. ; Cseh, Judit ; Laczy, Boglárka ; Tamaskó, Mónika ; Balla, J. ; Kappelmayer, J. ; Wágner, L. ; Wagner, Zoltán ; Csiky, Botond ; Nagy, J. ; Wittmann, I. / Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome. In: Kidney and Blood Pressure Research. 2008 ; Vol. 31, No. 1. pp. 47-54.
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AU - Szigeti, Nóra

AU - Markó, Lajos

AU - Molnár, Gerg A.

AU - Cseh, Judit

AU - Laczy, Boglárka

AU - Tamaskó, Mónika

AU - Balla, J.

AU - Kappelmayer, J.

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KW - Renal damage

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