Szérum "sex-hormone binding globulin" tartalom vizsgálata pajzsmirigybetegségekben.

Translated title of the contribution: Serum sex hormone-binding globulin levels in thyroid diseases

J. Földes, C. Bános, P. Lakatos, G. Tarján

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Synthesis of "sex-hormone binding globulin" is influenced by the thyroid hormones and its concentration in the serum may be a marker of the thyroid hormone effect at the peripheral tissue (liver) level. Compared to euthyroid controls serum "sex-hormone binding globulin" concentration is elevated in overt hyperthyroidism (141.6 +/- 37.6 vs 48.3 +/- 16.2 nmol/l; p less than 0.001), conversely, its mean level is decreased in the hypothyroid group of patients (24.9 +/- 14.8 vs 48.3 +/- 16.2; p less than 0.001). In the group of subclinical hyperthyroidism the mean value of "sex-hormone binding globulin" corresponds to that in control subjects (47.4 +/- 16.8), while its serum level is near the lower border of the normal range in subclinical hypothyroidism (33.6 +/- 6.1 vs 48.3 +/- 16.2; p less than 0.01). During thyroid hormone replacement for hypothyroidism measurement of serum "sex-hormone binding globulin" may help to assess the response of the target organs to the hormone therapy. In patients with peripheral thyroid hormone resistance serum "sex-hormone binding globulin" level is within the normal range (51.3 +/- 9.8), its determination supports the diagnosis of this disease.

Original languageHungarian
Pages (from-to)1579-1582
Number of pages4
JournalOrvosi Hetilap
Volume131
Issue number29
Publication statusPublished - Jul 22 1990

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Serum Globulins
Sex Hormone-Binding Globulin
Thyroid Diseases
Thyroid Hormones
Serum
Hyperthyroidism
Hypothyroidism
Reference Values
Thyroid Hormone Resistance Syndrome
Hormones
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szérum "sex-hormone binding globulin" tartalom vizsgálata pajzsmirigybetegségekben. / Földes, J.; Bános, C.; Lakatos, P.; Tarján, G.

In: Orvosi Hetilap, Vol. 131, No. 29, 22.07.1990, p. 1579-1582.

Research output: Contribution to journalArticle

Földes, J, Bános, C, Lakatos, P & Tarján, G 1990, 'Szérum "sex-hormone binding globulin" tartalom vizsgálata pajzsmirigybetegségekben.', Orvosi Hetilap, vol. 131, no. 29, pp. 1579-1582.
Földes, J. ; Bános, C. ; Lakatos, P. ; Tarján, G. / Szérum "sex-hormone binding globulin" tartalom vizsgálata pajzsmirigybetegségekben. In: Orvosi Hetilap. 1990 ; Vol. 131, No. 29. pp. 1579-1582.
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