Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer

Sebastian Schölch, Andreas Bogner, Ulrich Bork, Mohammad Rahbari, Balázs Győrffy, Martin Schneider, Christoph Reissfelder, Jürgen Weitz, Nuh N. Rahbari

Research output: Contribution to journalArticle

Abstract

The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p = 0.029; VC: HR 1.091; p = 0.009). Conversely, elevated EGF is associated with favorable DFS (TC: HR 0.998; p = 0.045; VC: HR 0.998; p = 0.018) but not OS (TC: p = 0.201; VC: p = 0.453). None of the other angiogenic cytokines correlated with prognosis. The prognostic value of PlGF (OS + DFS) and EGF (DFS) was confirmed in both independent retrospective cohorts. Serum PlGF and EGF may serve as prognostic markers in non-metastatic CRC.

Original languageEnglish
Article number10921
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer'. Together they form a unique fingerprint.

  • Cite this

    Schölch, S., Bogner, A., Bork, U., Rahbari, M., Győrffy, B., Schneider, M., Reissfelder, C., Weitz, J., & Rahbari, N. N. (2019). Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer. Scientific reports, 9(1), [10921]. https://doi.org/10.1038/s41598-019-47429-5