Serum lipid-lowering effect of vinca alkaloids

T. Kremmer, L. Holczinger, Susan Somfai-Relle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The serum lipid-lowering effect of monomeric and dimeric forms of Vinca alkaloids was studied on normal mice and on those with hyperlipidemia induced by ascites tumours (Ehrlich, NK/Ly). The decrease of serum lipid level after a single, non-toxic dose of these agents proved to be quick and reversible and there was no correlation between the hypolididemic effect and antitumour activity of drugs. Vinca alkaloids reduced first of all the neutral lipid (triglyceride) and very low density lipoprotein (VLDL) content of the serum. Decrease in VLDL level showed logarithmic correlation to the Vincristine dose applied. Simultaneously, higher doses increased the total lipid and triglyceride content of the liver.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalBiochemical Pharmacology
Volume28
Issue number2
DOIs
Publication statusPublished - 1979

Fingerprint

Vinca Alkaloids
Lipids
Serum
Ehrlich Tumor Carcinoma
VLDL Lipoproteins
Vincristine
Hyperlipidemias
Liver
Antineoplastic Agents
Tumors
Triglycerides
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Serum lipid-lowering effect of vinca alkaloids. / Kremmer, T.; Holczinger, L.; Somfai-Relle, Susan.

In: Biochemical Pharmacology, Vol. 28, No. 2, 1979, p. 227-230.

Research output: Contribution to journalArticle

Kremmer, T. ; Holczinger, L. ; Somfai-Relle, Susan. / Serum lipid-lowering effect of vinca alkaloids. In: Biochemical Pharmacology. 1979 ; Vol. 28, No. 2. pp. 227-230.
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