DER SERUMSPIEGEL DES SEZERNIERTEN INTERLEUKIN-2-REZEPTORS (sIL-2R); EIN LYMPHOZYTARER AKTIVITATSPARAMETER DER SARKOIDOSE

Translated title of the contribution: Serum levels of secreted interleukin-2 receptor (sIL-2R): A lymphocytic parameter reflecting sarcoidosis activity

J. Muller-Quernheim, J. Strausz, R. Ferlinz

Research output: Contribution to journalArticle

Abstract

Current concepts of the immunopathology of sarcoidosis indicate that activated pulmonary T-lymphocytes play a central role in the maintance of inflammatory processes. For the clinical management of the disease parameters which reflect the compartmentalized T-cell activation in the lung and which can be obtained from the peripheral blood are desired. Activated T-cells are known to release sIL-2R. Thus, we hypothesized that in pulmonary sarcoidosis disease activity could be monitored by the measurement of serum levels of sIL-2R. Our results demonstrate that disease activity is reflected more accurately by the serum level of sIL-2R than that of ACE, suggesting that phenomena of T-cell activation determining the course of the disease are monitored by this approach.

Original languageGerman
Pages (from-to)213-214
Number of pages2
JournalPneumologie, Sonderheft
Volume44
Issue number1
Publication statusPublished - 1990

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Interleukin-2 Receptors
Sarcoidosis
T-Lymphocytes
Serum
Pulmonary Sarcoidosis
Lung
Disease Management
Lung Diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

DER SERUMSPIEGEL DES SEZERNIERTEN INTERLEUKIN-2-REZEPTORS (sIL-2R); EIN LYMPHOZYTARER AKTIVITATSPARAMETER DER SARKOIDOSE. / Muller-Quernheim, J.; Strausz, J.; Ferlinz, R.

In: Pneumologie, Sonderheft, Vol. 44, No. 1, 1990, p. 213-214.

Research output: Contribution to journalArticle

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abstract = "Current concepts of the immunopathology of sarcoidosis indicate that activated pulmonary T-lymphocytes play a central role in the maintance of inflammatory processes. For the clinical management of the disease parameters which reflect the compartmentalized T-cell activation in the lung and which can be obtained from the peripheral blood are desired. Activated T-cells are known to release sIL-2R. Thus, we hypothesized that in pulmonary sarcoidosis disease activity could be monitored by the measurement of serum levels of sIL-2R. Our results demonstrate that disease activity is reflected more accurately by the serum level of sIL-2R than that of ACE, suggesting that phenomena of T-cell activation determining the course of the disease are monitored by this approach.",
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