Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins

G. Than, I. F. Csaba, D. G. Szabó, A. A. Arany, Z. J. Bognár, H. Bohn

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PP12 is one of the recently discovered soluble tissue antigens of the placenta. During normal pregnancy maternal serum PP12 levels rise during the first 18 weeks reaching a mean peak value of 139.9 ± 40.26 μg/l; after that there is a fall to a mean value of 111.9 ± 42.39 μg/l between 28 and 40 weeks. Significantly higher mean serum PP12 levels were found in the third trimester in two high risk pregnancy groups (281.09 ± 117.08 μg/l in pre-eclamptic toxaemia and 203.71 ± 73.77 μg/l in diabetes) while serum PP12 levels remained normal (114.94 ± 58.06 μg/l) in twin pregnancy. The increase of serum PP12 concentration in toxaemia and in diabetes may be of considerable diagnostic significance.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalArchives of Gynecology
Volume236
Issue number1
DOIs
Publication statusPublished - Oct 1984

Fingerprint

Pre-Eclampsia
Placenta
Pregnancy
Serum
Toxemia
Proteins
High-Risk Pregnancy
Twin Pregnancy
Third Pregnancy Trimester
Mothers
Antigens

Keywords

  • Elevated serum level of PP in toxaemic and diabetic patients
  • Placental protein 12 (PP)
  • PP serum levels in high-risk pregnancies
  • Radioimmunoassay of PP

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins. / Than, G.; Csaba, I. F.; Szabó, D. G.; Arany, A. A.; Bognár, Z. J.; Bohn, H.

In: Archives of Gynecology, Vol. 236, No. 1, 10.1984, p. 41-45.

Research output: Contribution to journalArticle

Than, G. ; Csaba, I. F. ; Szabó, D. G. ; Arany, A. A. ; Bognár, Z. J. ; Bohn, H. / Serum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by pre-eclampsia, diabetes or twins. In: Archives of Gynecology. 1984 ; Vol. 236, No. 1. pp. 41-45.
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