SEZERNIERTER INTERLEUKIN-2-REZEPTOR ALS AKTIVITATSPARAMETER DER SARKOIDOSE

Translated title of the contribution: Serum level of soluble interleukin-2 receptor (sIL-2-R) in sarcoidosis as a measure of disease activity

J. Strausz, J. Muller-Quernheim, R. Ferlinz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Serum sIL-2-R levels were measured in 28 sarcoidosis patients at multiple time points before, during, and after therapy, with a mean follow-up time of 10.2 ± 5.2 months, and the results compared with the clinical activity of the disease. Before therapy, 20 out of 24 episodes with active disease exhibited elevated levels of sIL-2-R (918 ± 362 U/ml). In inactive disease after tapering off corticoid therapy the sIL-2-R levels were 453 ± 274 U/ml. Disease activity under therapy also correlated with sIL-2-R serum levels. 23 out of 29 episodes with signs of activity under therapy had elevated sIL-2-R levels (808 ± 409 U/ml). Only three of 28 patients in whom disease activity ceased after therapy had been initiated had raised sIL-2-R levels (mean: 401 ± 140 U/ml). These results demonstrate that the activity of pulmonary sarcoidosis is reflected accurately by the serum levels of sIL-2-R, suggesting that the course of the disease can be monitored by this approach.

Translated title of the contributionSerum level of soluble interleukin-2 receptor (sIL-2-R) in sarcoidosis as a measure of disease activity
Original languageGerman
Pages (from-to)744-749
Number of pages6
JournalDeutsche Medizinische Wochenschrift
Volume114
Issue number19
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Medicine(all)

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