Serum IgG and IgM ganglioside GM1 antibodies in patients with multiple sclerosis.

Emilia Zaprianova, Katalin Majtényi, Denislava Deleva, Olia Mikova, Andon Filchev, Borislav Sultanov, Vera Kolyovska, Emil Sultanov, Lilia Christova, Xenia Kmetska, Dimitar Georgiev

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Abstract

INTRODUCTION: In order to obtain more information concerning the pathogenic significance of ganglioside GM1 in multiple sclerosis serum polyclonal IgG and IgM antibodies to GM1 were evaluated in multiple sclerosis patients with relapsing-remitting and secondary progressive forms of the disease. PATIENTS AND METHODS: The evaluated sera were from 55 patients with clinically definite multiple sclerosis and from 20 healthy subjects. Forty-two of patients were with relapsing-remitting and 13 with secondary progressive multiple sclerosis. Antibodies to GM1 were measured using a modification of the enzyme-linked immunosorbent assay technique of Mizutamari et al (1994). RESULTS: A statistically significant difference of serum IgG antibody titres to GM1 was found between the healthy subjects and the multiple sclerosis patients with relapsing-remitting form of the disease (p = 0.04), as well as of serum IgG antibody titres to GM1 between the patients with relapsing-remitting multiple sclerosis in relapse and in remission (p = 0.01). CONCLUSION: Bearing in mind the heterogeneity of multiple sclerosis, the pathogenic significance of serum antibodies to GM1 should be interpreted concerning the precise clinical form of the disease and not the whole group of MS patients. The findings in this study argue for the possible involvement of ganglioside GM1 in the pathogenesis of demyelination in relapsing-remitting multiple sclerosis.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalIdeggyógyászati szemle
Volume57
Issue number3-4
Publication statusPublished - Mar 20 2004

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Zaprianova, E., Majtényi, K., Deleva, D., Mikova, O., Filchev, A., Sultanov, B., Kolyovska, V., Sultanov, E., Christova, L., Kmetska, X., & Georgiev, D. (2004). Serum IgG and IgM ganglioside GM1 antibodies in patients with multiple sclerosis. Ideggyógyászati szemle, 57(3-4), 94-99.