Serum fetuin-A levels inversely correlate with the severity of arterial calcification in patients with chronic lower extremity atherosclerosis without renal disease

Z. Szeberin, M. Fehérvári, M. Krepuska, A. Apor, E. Rimely, H. Sarkadi, G. Széplaki, Z. Prohászka, L. Kalabay, G. Acsády

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aim. Fetuin-A is a hepatic glycoprotein that inhibits extraosseous calcification. Lower serum fetuin-A concentration was associated with severe arterial calcification in patients with end stage renal disease. We evaluated the association of serum fetuin-A levels and the severity of atherosclerosis in patients with peripheral vascular disease having normal renal function. Methods. In this cross-sectional study among 93 chronic atherosclerotic patients with lower extremity vascular disease, systemic atherosclerosis and calcification was assessed by ultrasound (carotid intima-media thickness/IMT/, calcification at the abdominal aorta, carotid and femoral bifurcations, aortic and mitral valves) and angiography (Bollinger score). Standard serum markers of inflammation, diabetes, renal function, ankle-brachial indexes and traditional risk factors for atherosclerosis were noted and Fontaine classification was applied for the severity of symptoms. Results. The patients mean (SD) age was 59.95 (7.61) years, 78% were men, 35% had diabetes. Serum fetuin-A level showed significant negative correlation with ultrasound calcification score (P=0.018, r=-0.257) and Bollinger angiographic score (P=0.035, r=-0.347). Fetuin-A did not correlate with IMT or Fontaine classification. Fetuin-A also showed significant correlation with albumin, transferrin and hemoglobin A1c (r=0.287, 0.305 and 0.219, respectively at P

Original languageEnglish
Pages (from-to)474-480
Number of pages7
JournalInternational Angiology
Volume30
Issue number5
Publication statusPublished - Oct 2011

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alpha-2-HS-Glycoprotein
Lower Extremity
Atherosclerosis
Kidney
Serum
Ankle Brachial Index
Carotid Intima-Media Thickness
Peripheral Vascular Diseases
Abdominal Aorta
Transferrin
Thigh
Aortic Valve
Mitral Valve
Vascular Diseases
Chronic Kidney Failure
Albumins
Glycoproteins
Angiography
Hemoglobins
Cross-Sectional Studies

Keywords

  • Atherosclerosis
  • Calcification, physiologic
  • Vascular diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Serum fetuin-A levels inversely correlate with the severity of arterial calcification in patients with chronic lower extremity atherosclerosis without renal disease. / Szeberin, Z.; Fehérvári, M.; Krepuska, M.; Apor, A.; Rimely, E.; Sarkadi, H.; Széplaki, G.; Prohászka, Z.; Kalabay, L.; Acsády, G.

In: International Angiology, Vol. 30, No. 5, 10.2011, p. 474-480.

Research output: Contribution to journalArticle

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abstract = "Aim. Fetuin-A is a hepatic glycoprotein that inhibits extraosseous calcification. Lower serum fetuin-A concentration was associated with severe arterial calcification in patients with end stage renal disease. We evaluated the association of serum fetuin-A levels and the severity of atherosclerosis in patients with peripheral vascular disease having normal renal function. Methods. In this cross-sectional study among 93 chronic atherosclerotic patients with lower extremity vascular disease, systemic atherosclerosis and calcification was assessed by ultrasound (carotid intima-media thickness/IMT/, calcification at the abdominal aorta, carotid and femoral bifurcations, aortic and mitral valves) and angiography (Bollinger score). Standard serum markers of inflammation, diabetes, renal function, ankle-brachial indexes and traditional risk factors for atherosclerosis were noted and Fontaine classification was applied for the severity of symptoms. Results. The patients mean (SD) age was 59.95 (7.61) years, 78{\%} were men, 35{\%} had diabetes. Serum fetuin-A level showed significant negative correlation with ultrasound calcification score (P=0.018, r=-0.257) and Bollinger angiographic score (P=0.035, r=-0.347). Fetuin-A did not correlate with IMT or Fontaine classification. Fetuin-A also showed significant correlation with albumin, transferrin and hemoglobin A1c (r=0.287, 0.305 and 0.219, respectively at P",
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AU - Szeberin, Z.

AU - Fehérvári, M.

AU - Krepuska, M.

AU - Apor, A.

AU - Rimely, E.

AU - Sarkadi, H.

AU - Széplaki, G.

AU - Prohászka, Z.

AU - Kalabay, L.

AU - Acsády, G.

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