Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease

A novel liver disease biomarker

G. Firneisz, Tímea Varga, G. Lengyel, J. Fehér, Dóra Ghyczy, Barna Wichmann, L. Selmeci, Z. Tulassay, K. Rácz, A. Somogyi

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Abstract

Background: In a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin nai{dotless}̈ve patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL). Methods and Findings: sDPP-4 was measured by kinetic assay in 39 NAFLD (F/M:19/20, mean age: 47.42 yrs) and 82 type 2 diabetes (F/M:48/34, 62.8 yrs) patients and 26 (F/M:14/12, 35.3 yrs) controls. Definition of T2D group as patients with type 2 diabetes but without clinically obvious liver disease created non-overlapping study groups. Diagnosis of NAFLD was based on ultrasonography and the exclusion of other etiololgy. Patients in T2D and NAFLD groups were similarly obese. 75 g CH OGTT in 39 NAFLD patients: 24-NGT, 4-IGT or IFG ("prediabetes"), 11-type 2 diabetes. HOMA2-IR: CNTRL: 1.44; T2D-group: 2.62 (p = 0.046 vs CNTRL, parametric tests); NAFLD(NGTonly): 3.23 (p = 0.0013 vs CNTRL); NAFLD(IFG/IGT/type 2 diabetes): 3.82 (p

Original languageEnglish
Article numbere12226
JournalPLoS One
Volume5
Issue number8
DOIs
Publication statusPublished - 2010

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Dipeptidyl Peptidase 4
peptidases
fatty liver
liver diseases
Biomarkers
insulin resistance
Liver
Liver Diseases
biomarkers
Insulin
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Medical problems
Serum
Insulated gate bipolar transistors (IGBT)
Dipeptidyl-Peptidase IV Inhibitors
Prediabetic State
Ultrasonography
Glucose Tolerance Test
Non-alcoholic Fatty Liver Disease

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

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title = "Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease: A novel liver disease biomarker",
abstract = "Background: In a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin nai{dotless}̈ve patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL). Methods and Findings: sDPP-4 was measured by kinetic assay in 39 NAFLD (F/M:19/20, mean age: 47.42 yrs) and 82 type 2 diabetes (F/M:48/34, 62.8 yrs) patients and 26 (F/M:14/12, 35.3 yrs) controls. Definition of T2D group as patients with type 2 diabetes but without clinically obvious liver disease created non-overlapping study groups. Diagnosis of NAFLD was based on ultrasonography and the exclusion of other etiololgy. Patients in T2D and NAFLD groups were similarly obese. 75 g CH OGTT in 39 NAFLD patients: 24-NGT, 4-IGT or IFG ({"}prediabetes{"}), 11-type 2 diabetes. HOMA2-IR: CNTRL: 1.44; T2D-group: 2.62 (p = 0.046 vs CNTRL, parametric tests); NAFLD(NGTonly): 3.23 (p = 0.0013 vs CNTRL); NAFLD(IFG/IGT/type 2 diabetes): 3.82 (p",
author = "G. Firneisz and T{\'i}mea Varga and G. Lengyel and J. Feh{\'e}r and D{\'o}ra Ghyczy and Barna Wichmann and L. Selmeci and Z. Tulassay and K. R{\'a}cz and A. Somogyi",
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T1 - Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease

T2 - A novel liver disease biomarker

AU - Firneisz, G.

AU - Varga, Tímea

AU - Lengyel, G.

AU - Fehér, J.

AU - Ghyczy, Dóra

AU - Wichmann, Barna

AU - Selmeci, L.

AU - Tulassay, Z.

AU - Rácz, K.

AU - Somogyi, A.

PY - 2010

Y1 - 2010

N2 - Background: In a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin nai{dotless}̈ve patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL). Methods and Findings: sDPP-4 was measured by kinetic assay in 39 NAFLD (F/M:19/20, mean age: 47.42 yrs) and 82 type 2 diabetes (F/M:48/34, 62.8 yrs) patients and 26 (F/M:14/12, 35.3 yrs) controls. Definition of T2D group as patients with type 2 diabetes but without clinically obvious liver disease created non-overlapping study groups. Diagnosis of NAFLD was based on ultrasonography and the exclusion of other etiololgy. Patients in T2D and NAFLD groups were similarly obese. 75 g CH OGTT in 39 NAFLD patients: 24-NGT, 4-IGT or IFG ("prediabetes"), 11-type 2 diabetes. HOMA2-IR: CNTRL: 1.44; T2D-group: 2.62 (p = 0.046 vs CNTRL, parametric tests); NAFLD(NGTonly): 3.23 (p = 0.0013 vs CNTRL); NAFLD(IFG/IGT/type 2 diabetes): 3.82 (p

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