Serum DHAS in the maternal-fetoplacental system during the 28th-40th weeks of pregnancy

P. Hercz, L. Ungár, P. Siklós, R. G. Farquharson

Research output: Contribution to journalArticle

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Abstract

The authors measured the serum levels of dehydroepiandrosterone sulfate (DHAS) in the maternal vein (MV), the umbilical vein (UV) and the umbilical artery (UA) during the 28th-36th weeks of pregnancy (n = 74) and in the 40th week (n = 34), to clarify the hormonal changes that occur between the maternal and fetal compartments. The following results were found: (1) The DHAS concentration increased significantly in MV, up to twice the concentration from the 28th-32nd weeks to the 33rd-36th weeks (p <0.01). From the 33rd-36th weeks to the 40th week it decreased significantly to one third of this value (p <0.01). DHAS levels revealed a decreasing tendency in the UA and UV serum from the 28th-32nd weeks to the 33rd-36th weeks, and there was a tendency to rise from the 33rd-36th weeks to the 40th week. (2) The serum DHAS values were found to be higher than in the MV, the UA-UV difference was not significant; however, the 'UA/UV × 100' value remained higher than 100% during the 28th-40th weeks. (3) The MV DHAS value showed slight correlation with the UV and UA DHAS concentration (r = 0.2951, p <0.01, n = 106; r = 0.2930, p <0.01, n = 100). There was a close correlation between the UV and UA serum DHAS levels (r = 0.8432, p <0.01, n = 98). The authors consider that the adrenal activity increases independently of the maternal adrenal cortex at term.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume29
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Dehydroepiandrosterone Sulfate
Umbilical Veins
Umbilical Arteries
Mothers
Pregnancy
Serum
Veins
Adrenal Cortex

Keywords

  • 28th-40th weeks of pregnancy
  • DHAS
  • Fetal adrenal cortex
  • Fetoplacental-unit
  • Maternal serum
  • Umbilical artery serum
  • Umbilical vein serum

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Serum DHAS in the maternal-fetoplacental system during the 28th-40th weeks of pregnancy. / Hercz, P.; Ungár, L.; Siklós, P.; Farquharson, R. G.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 29, No. 1, 1988, p. 1-5.

Research output: Contribution to journalArticle

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abstract = "The authors measured the serum levels of dehydroepiandrosterone sulfate (DHAS) in the maternal vein (MV), the umbilical vein (UV) and the umbilical artery (UA) during the 28th-36th weeks of pregnancy (n = 74) and in the 40th week (n = 34), to clarify the hormonal changes that occur between the maternal and fetal compartments. The following results were found: (1) The DHAS concentration increased significantly in MV, up to twice the concentration from the 28th-32nd weeks to the 33rd-36th weeks (p <0.01). From the 33rd-36th weeks to the 40th week it decreased significantly to one third of this value (p <0.01). DHAS levels revealed a decreasing tendency in the UA and UV serum from the 28th-32nd weeks to the 33rd-36th weeks, and there was a tendency to rise from the 33rd-36th weeks to the 40th week. (2) The serum DHAS values were found to be higher than in the MV, the UA-UV difference was not significant; however, the 'UA/UV × 100' value remained higher than 100{\%} during the 28th-40th weeks. (3) The MV DHAS value showed slight correlation with the UV and UA DHAS concentration (r = 0.2951, p <0.01, n = 106; r = 0.2930, p <0.01, n = 100). There was a close correlation between the UV and UA serum DHAS levels (r = 0.8432, p <0.01, n = 98). The authors consider that the adrenal activity increases independently of the maternal adrenal cortex at term.",
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