Serum amino acid levels as a possible diagnostic differentiation between essential tremor and Parkinsonian tremor

J. Málly, G. Szalai, Trevor W. Stone

Research output: Contribution to journalArticle

Abstract

When tremor is the presenting symptom, a differential diagnosis between early stages of essential (familial) tremor and Parkinson's disease is extremely difficult. In this study, we measured the levels of 17 amino acids in the serum of patients with tremor as an early symptom of confirmed essential tremor or Parkinson's disease. The arginine and methionine levels were significantly lower in Parkinson's patients than in controls, whereas valine levels were elevated. In contrast, the amounts of asparagine, serine, glutamine, arginine, tyramine, methionine, isoleucine and lysine were all lower in patients with essential tremor than in controls. Glutamine, glycine, tyrosine, alanine, methionine and isoleucine levels were significantly different between Parkinson's and essential tremor patients. We propose that a consideration of the levels of amino acids may be a useful diagnostic criterion, aiding the discrimination and thus early appropriate treatment of the two disorders.

Original languageEnglish
Pages (from-to)519-520
Number of pages2
JournalMedical Science Research
Volume25
Issue number8
Publication statusPublished - 1997

Fingerprint

Essential Tremor
Tremor
Methionine
Isoleucine
Glutamine
Amino Acids
Arginine
Serum
Tyramine
Asparagine
Valine
Parkinson Disease
Alanine
Glycine
Serine
Lysine
Tyrosine
Differential Diagnosis

Keywords

  • Amino acids
  • Essential tremor
  • Parkinson's disease
  • Tremor disorders

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Serum amino acid levels as a possible diagnostic differentiation between essential tremor and Parkinsonian tremor. / Málly, J.; Szalai, G.; Stone, Trevor W.

In: Medical Science Research, Vol. 25, No. 8, 1997, p. 519-520.

Research output: Contribution to journalArticle

@article{e1be218848b74ed6997052f13d6d3614,
title = "Serum amino acid levels as a possible diagnostic differentiation between essential tremor and Parkinsonian tremor",
abstract = "When tremor is the presenting symptom, a differential diagnosis between early stages of essential (familial) tremor and Parkinson's disease is extremely difficult. In this study, we measured the levels of 17 amino acids in the serum of patients with tremor as an early symptom of confirmed essential tremor or Parkinson's disease. The arginine and methionine levels were significantly lower in Parkinson's patients than in controls, whereas valine levels were elevated. In contrast, the amounts of asparagine, serine, glutamine, arginine, tyramine, methionine, isoleucine and lysine were all lower in patients with essential tremor than in controls. Glutamine, glycine, tyrosine, alanine, methionine and isoleucine levels were significantly different between Parkinson's and essential tremor patients. We propose that a consideration of the levels of amino acids may be a useful diagnostic criterion, aiding the discrimination and thus early appropriate treatment of the two disorders.",
keywords = "Amino acids, Essential tremor, Parkinson's disease, Tremor disorders",
author = "J. M{\'a}lly and G. Szalai and Stone, {Trevor W.}",
year = "1997",
language = "English",
volume = "25",
pages = "519--520",
journal = "Medical Science Research",
issn = "0269-8951",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Serum amino acid levels as a possible diagnostic differentiation between essential tremor and Parkinsonian tremor

AU - Málly, J.

AU - Szalai, G.

AU - Stone, Trevor W.

PY - 1997

Y1 - 1997

N2 - When tremor is the presenting symptom, a differential diagnosis between early stages of essential (familial) tremor and Parkinson's disease is extremely difficult. In this study, we measured the levels of 17 amino acids in the serum of patients with tremor as an early symptom of confirmed essential tremor or Parkinson's disease. The arginine and methionine levels were significantly lower in Parkinson's patients than in controls, whereas valine levels were elevated. In contrast, the amounts of asparagine, serine, glutamine, arginine, tyramine, methionine, isoleucine and lysine were all lower in patients with essential tremor than in controls. Glutamine, glycine, tyrosine, alanine, methionine and isoleucine levels were significantly different between Parkinson's and essential tremor patients. We propose that a consideration of the levels of amino acids may be a useful diagnostic criterion, aiding the discrimination and thus early appropriate treatment of the two disorders.

AB - When tremor is the presenting symptom, a differential diagnosis between early stages of essential (familial) tremor and Parkinson's disease is extremely difficult. In this study, we measured the levels of 17 amino acids in the serum of patients with tremor as an early symptom of confirmed essential tremor or Parkinson's disease. The arginine and methionine levels were significantly lower in Parkinson's patients than in controls, whereas valine levels were elevated. In contrast, the amounts of asparagine, serine, glutamine, arginine, tyramine, methionine, isoleucine and lysine were all lower in patients with essential tremor than in controls. Glutamine, glycine, tyrosine, alanine, methionine and isoleucine levels were significantly different between Parkinson's and essential tremor patients. We propose that a consideration of the levels of amino acids may be a useful diagnostic criterion, aiding the discrimination and thus early appropriate treatment of the two disorders.

KW - Amino acids

KW - Essential tremor

KW - Parkinson's disease

KW - Tremor disorders

UR - http://www.scopus.com/inward/record.url?scp=0030765452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030765452&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030765452

VL - 25

SP - 519

EP - 520

JO - Medical Science Research

JF - Medical Science Research

SN - 0269-8951

IS - 8

ER -