Serum amino acid levels as a possible diagnostic differentiation between essential tremor and Parkinsonian tremor

Judit Mally, Gabriella Szalai, Trevor W. Stone

Research output: Contribution to journalArticle

Abstract

When tremor is the presenting symptom, a differential diagnosis between early stages of essential (familial) tremor and Parkinson's disease is extremely difficult. In this study, we measured the levels of 17 amino acids in the serum of patients with tremor as an early symptom of confirmed essential tremor or Parkinson's disease. The arginine and methionine levels were significantly lower in Parkinson's patients than in controls, whereas valine levels were elevated. In contrast, the amounts of asparagine, serine, glutamine, arginine, tyramine, methionine, isoleucine and lysine were all lower in patients with essential tremor than in controls. Glutamine, glycine, tyrosine, alanine, methionine and isoleucine levels were significantly different between Parkinson's and essential tremor patients. We propose that a consideration of the levels of amino acids may be a useful diagnostic criterion, aiding the discrimination and thus early appropriate treatment of the two disorders.

Original languageEnglish
Pages (from-to)519-520
Number of pages2
JournalMedical Science Research
Volume25
Issue number8
Publication statusPublished - Sep 25 1997

Keywords

  • Amino acids
  • Essential tremor
  • Parkinson's disease
  • Tremor disorders

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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