Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: A possible new mechanism for hypoxia-induced vasodilatation of the rat heart

G. Burnstock, J. Lincoln, E. Fehér, A. M. Hopwood, K. Kirkpatrick, P. Milner, V. Ralevic

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

In this report we demonstrate the immunocytochemical localization of serotonin in endothelial cells of rat coronary vessels and a significant increase in the release of serotonin into the perfusate of Langendorff rat heart preparations during hypoxia. It is suggested that serotonin, localized in endothelial cells, is released during hypoxia and could provide part of a pathophysiological mechanism for vasodilatation to protect the heart from damage due to hypoxia.

Original languageEnglish
Pages (from-to)705-707
Number of pages3
JournalExperientia
Volume44
Issue number8
DOIs
Publication statusPublished - Aug 1988

Fingerprint

Endothelial cells
Vasodilation
Rats
Serotonin
Coronary Vessels
Endothelial Cells
Hypoxia

Keywords

  • endothelial cells
  • Heart
  • hypoxia
  • serotonin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia : A possible new mechanism for hypoxia-induced vasodilatation of the rat heart. / Burnstock, G.; Lincoln, J.; Fehér, E.; Hopwood, A. M.; Kirkpatrick, K.; Milner, P.; Ralevic, V.

In: Experientia, Vol. 44, No. 8, 08.1988, p. 705-707.

Research output: Contribution to journalArticle

Burnstock, G. ; Lincoln, J. ; Fehér, E. ; Hopwood, A. M. ; Kirkpatrick, K. ; Milner, P. ; Ralevic, V. / Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia : A possible new mechanism for hypoxia-induced vasodilatation of the rat heart. In: Experientia. 1988 ; Vol. 44, No. 8. pp. 705-707.
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