Serotonin content of the brain stem nuclei in the rat

M. Palkovits, M. Brownstein, J. M. Saavedra

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

The serotonin (5-hydroxytryptamine; 5-HT) concentrations of 55 individual brain stem regions were determined by use of a specific and sensitive enzymatic isotopic technique in the rat. Serotonin was unevenly distributed throughout all the brain stem areas examined. The highest concentrations of 5-HT (above 20 ng/mg protein) were found in certain of the raphe nuclei. A high amount of 5-HT was also measured in the substantia nigra and in the globus pallidus. The central and tegmental gray matters of the mesencephalon and pons contained moderate amounts of 5-HT. The nuclei of reticular formation all contained about the same amount of 5-HT. There was more than a 5-fold difference between the highest and lowest concentrations of 5-HT measured in the cranial nerve nuclei. The motor nerve nuclei seemed to contain more of the amine than the sensory nerve nuclei.

Original languageEnglish
Pages (from-to)237-249
Number of pages13
JournalBrain Research
Volume80
Issue number2
DOIs
Publication statusPublished - Nov 15 1974

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Brain Stem
Serotonin
Globus Pallidus
Raphe Nuclei
Reticular Formation
Pons
Cranial Nerves
Substantia Nigra
Mesencephalon
Amines

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Serotonin content of the brain stem nuclei in the rat. / Palkovits, M.; Brownstein, M.; Saavedra, J. M.

In: Brain Research, Vol. 80, No. 2, 15.11.1974, p. 237-249.

Research output: Contribution to journalArticle

Palkovits, M. ; Brownstein, M. ; Saavedra, J. M. / Serotonin content of the brain stem nuclei in the rat. In: Brain Research. 1974 ; Vol. 80, No. 2. pp. 237-249.
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