Serotonin content of the brain stem nuclei in the rat

M. Palkovits, M. Brownstein, J. M. Saavedra

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The serotonin (5-hydroxytryptamine; 5-HT) concentrations of 55 individual brain stem regions were determined by use of a specific and sensitive enzymatic isotopic technique in the rat. Serotonin was unevenly distributed throughout all the brain stem areas examined. The highest concentrations of 5-HT (above 20 ng/mg protein) were found in certain of the raphe nuclei. A high amount of 5-HT was also measured in the substantia nigra and in the globus pallidus. The central and tegmental gray matters of the mesencephalon and pons contained moderate amounts of 5-HT. The nuclei of reticular formation all contained about the same amount of 5-HT. There was more than a 5-fold difference between the highest and lowest concentrations of 5-HT measured in the cranial nerve nuclei. The motor nerve nuclei seemed to contain more of the amine than the sensory nerve nuclei.

Original languageEnglish
Pages (from-to)237-249
Number of pages13
JournalBrain research
Issue number2
Publication statusPublished - Nov 15 1974

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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