Serotonergic innervation of the rat pituitary intermediate lobe: Decrease after stalk section

E. Friedman, D. T. Krieger, E. Mezey, C. Léránth, M. J. Brownstein, M. Palkóvits

Research output: Contribution to journalArticle

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Abstract

Serotonin (5-HT)-containing nerve fibers and terminals, but not cell bodies, have been demonstrated by light and electron microscopic immunocytochemistry in the intermediate lobe of the rat pituitary. Seven days after pituitary stalk transection, 5-HT immunoreactive fibers disappeared almost entirely from the intermediate lobe. Intermediate lobe 5-HT and 5-hydroxyindoleacetic acid concentrations, measured by high pressure liquid chromatography coupled to electrochemical detection, fell to 56% and 62% of control, respectively. There were no changes in 5-HT concentrations in anterior or posterior lobes of the pituitary or in the median eminence. These findings, and the failure of sympathectomy to cause a drop in pars intermedia 5-HT, indicate that in the intermediate lobe of the pituitary neuronal 5-HT originates in cells situated in the central nervous system.

Original languageEnglish
Pages (from-to)1943-1947
Number of pages5
JournalEndocrinology
Volume112
Issue number6
Publication statusPublished - 1983

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Intermediate Pituitary Gland
Serotonin
Posterior Pituitary Gland
Median Eminence
Hydroxyindoleacetic Acid
Sympathectomy
Pituitary Gland
Nerve Fibers
Central Nervous System
Immunohistochemistry
High Pressure Liquid Chromatography
Electrons
Light

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Friedman, E., Krieger, D. T., Mezey, E., Léránth, C., Brownstein, M. J., & Palkóvits, M. (1983). Serotonergic innervation of the rat pituitary intermediate lobe: Decrease after stalk section. Endocrinology, 112(6), 1943-1947.

Serotonergic innervation of the rat pituitary intermediate lobe : Decrease after stalk section. / Friedman, E.; Krieger, D. T.; Mezey, E.; Léránth, C.; Brownstein, M. J.; Palkóvits, M.

In: Endocrinology, Vol. 112, No. 6, 1983, p. 1943-1947.

Research output: Contribution to journalArticle

Friedman, E, Krieger, DT, Mezey, E, Léránth, C, Brownstein, MJ & Palkóvits, M 1983, 'Serotonergic innervation of the rat pituitary intermediate lobe: Decrease after stalk section', Endocrinology, vol. 112, no. 6, pp. 1943-1947.
Friedman E, Krieger DT, Mezey E, Léránth C, Brownstein MJ, Palkóvits M. Serotonergic innervation of the rat pituitary intermediate lobe: Decrease after stalk section. Endocrinology. 1983;112(6):1943-1947.
Friedman, E. ; Krieger, D. T. ; Mezey, E. ; Léránth, C. ; Brownstein, M. J. ; Palkóvits, M. / Serotonergic innervation of the rat pituitary intermediate lobe : Decrease after stalk section. In: Endocrinology. 1983 ; Vol. 112, No. 6. pp. 1943-1947.
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