Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele

Gábor Telkes, K. Rajczy, Marina Varga, Antal Péter, Z. Tulassay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives Renal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort. Materials and methods Data of 709 uraemic patients were collected and analyzed from 2001-2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD: ±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG. Results Of 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P

Original languageEnglish
Pages (from-to)906-911
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume20
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Seroepidemiologic Studies
Helicobacter pylori
Alleles
Histocompatibility Testing
MHC Class II Genes
Uremia
Helicobacter Infections
HLA Antigens
HLA-DR12 antigen
Immunoglobulin G
Kidney
Polymerase Chain Reaction
Enzymes
Infection

Keywords

  • Helicobacter pylori
  • HLA-DR antigens
  • Kidney failure
  • Renal insufficiency
  • Seroepidemiologic studies
  • Seroprevalence

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

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title = "Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele",
abstract = "Objectives Renal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort. Materials and methods Data of 709 uraemic patients were collected and analyzed from 2001-2006. 58.7{\%} of patients were male, 41.3{\%} were female, mean age was 45.1 years (SD: ±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG. Results Of 709 patients, 49.37{\%} were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P",
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T1 - Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele

AU - Telkes, Gábor

AU - Rajczy, K.

AU - Varga, Marina

AU - Péter, Antal

AU - Tulassay, Z.

PY - 2008/9

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N2 - Objectives Renal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort. Materials and methods Data of 709 uraemic patients were collected and analyzed from 2001-2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD: ±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG. Results Of 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P

AB - Objectives Renal disease at any stage is often accompanied by significant gastrointestinal symptoms, and Helicobacter pylori (H. pylori) is closely related to these disorders. A debate is still ongoing on the clinical significance of coexisting uraemia and H. pylori. HLA-class II genes have been repeatedly investigated for predisposition to H. pylori infection. The aim of our work was to evaluate the infection rate among uraemic patients, and study the relationship between HLA antigens and H. pylori serologic status in the same cohort. Materials and methods Data of 709 uraemic patients were collected and analyzed from 2001-2006. 58.7% of patients were male, 41.3% were female, mean age was 45.1 years (SD: ±14.65). Microlymphocytotoxicity assay was used for typing of HLA class I, PCR-SSP for typing HLA class II alleles and enzyme immunofluorescency for specific H. pylori IgG. Results Of 709 patients, 49.37% were seropositive for H. pylori. Age of H. pylori positive patients was 48.9 versus 41 years of negatives (P

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KW - Seroprevalence

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