Abstract
Purpose. To determine the seroprevalence of specific IgM indicative of respiratory tract infection (RTI) due to Chlamydia trachomatis (CT) among symptomatic infants. Methodology. A descriptive study was conducted on young infants up to 5 months old at the Bacterial Sexually Transmitted Infections Reference Laboratory, National Centre for Epidemiology, Budapest, covering the period 2008–2016. Serum samples from infants suffering from RTIs were screened with a micro-immunofluorescence test (Focus, Cypress, USA) for the presence of anti-Chlamydia trachomatis-specific IgM. A parallel Bordetella pertussis screening was performed by an indirect immunofluorescence test (Euroimmun, Lübeck, Germany) that detected specific IgM. Results.The CT-specific serum IgM was highly reactive in 50 (19.1%) of the 262 neonates with RTIs, while all proved negative for Bordetella pertussis-specific IgM. Conclusion. Vertically transmitted C. trachomatis must be regarded as a common pathogen among symptomatic neonates with RTIs in Hungary. Routine screening and treatment of pregnant women could be one option to help prevent these conditions. Focused laboratory testing based on raised clinical awareness should enable early diagnosis and appropriate therapy for symptomatic infants.
| Original language | English |
|---|---|
| Pages (from-to) | 1114-1117 |
| Number of pages | 4 |
| Journal | Journal of Medical Microbiology |
| Volume | 66 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Chlamydia trachomatis
- IgM
- Neonatal
- Respiratory tract infection
- Serology
- Vertical transmission
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)
Cite this
Seroprevalence of anti-chlamydia trachomatis IGM in neonatal respiratory tract infections in Hungary. / Balla, Eszter; Donders, Gilbert G.G.; Petrovay, Fruzsina; Urbán, E.
In: Journal of Medical Microbiology, Vol. 66, No. 8, 01.08.2017, p. 1114-1117.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Seroprevalence of anti-chlamydia trachomatis IGM in neonatal respiratory tract infections in Hungary
AU - Balla, Eszter
AU - Donders, Gilbert G.G.
AU - Petrovay, Fruzsina
AU - Urbán, E.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Purpose. To determine the seroprevalence of specific IgM indicative of respiratory tract infection (RTI) due to Chlamydia trachomatis (CT) among symptomatic infants. Methodology. A descriptive study was conducted on young infants up to 5 months old at the Bacterial Sexually Transmitted Infections Reference Laboratory, National Centre for Epidemiology, Budapest, covering the period 2008–2016. Serum samples from infants suffering from RTIs were screened with a micro-immunofluorescence test (Focus, Cypress, USA) for the presence of anti-Chlamydia trachomatis-specific IgM. A parallel Bordetella pertussis screening was performed by an indirect immunofluorescence test (Euroimmun, Lübeck, Germany) that detected specific IgM. Results.The CT-specific serum IgM was highly reactive in 50 (19.1%) of the 262 neonates with RTIs, while all proved negative for Bordetella pertussis-specific IgM. Conclusion. Vertically transmitted C. trachomatis must be regarded as a common pathogen among symptomatic neonates with RTIs in Hungary. Routine screening and treatment of pregnant women could be one option to help prevent these conditions. Focused laboratory testing based on raised clinical awareness should enable early diagnosis and appropriate therapy for symptomatic infants.
AB - Purpose. To determine the seroprevalence of specific IgM indicative of respiratory tract infection (RTI) due to Chlamydia trachomatis (CT) among symptomatic infants. Methodology. A descriptive study was conducted on young infants up to 5 months old at the Bacterial Sexually Transmitted Infections Reference Laboratory, National Centre for Epidemiology, Budapest, covering the period 2008–2016. Serum samples from infants suffering from RTIs were screened with a micro-immunofluorescence test (Focus, Cypress, USA) for the presence of anti-Chlamydia trachomatis-specific IgM. A parallel Bordetella pertussis screening was performed by an indirect immunofluorescence test (Euroimmun, Lübeck, Germany) that detected specific IgM. Results.The CT-specific serum IgM was highly reactive in 50 (19.1%) of the 262 neonates with RTIs, while all proved negative for Bordetella pertussis-specific IgM. Conclusion. Vertically transmitted C. trachomatis must be regarded as a common pathogen among symptomatic neonates with RTIs in Hungary. Routine screening and treatment of pregnant women could be one option to help prevent these conditions. Focused laboratory testing based on raised clinical awareness should enable early diagnosis and appropriate therapy for symptomatic infants.
KW - Chlamydia trachomatis
KW - IgM
KW - Neonatal
KW - Respiratory tract infection
KW - Serology
KW - Vertical transmission
UR - http://www.scopus.com/inward/record.url?scp=85029470963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029470963&partnerID=8YFLogxK
U2 - 10.1099/jmm.0.000557
DO - 10.1099/jmm.0.000557
M3 - Article
AN - SCOPUS:85029470963
VL - 66
SP - 1114
EP - 1117
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
SN - 0022-2615
IS - 8
ER -