Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary

Annika Haagsman, G. Reuter, Erwin Duizer, Gyuláné Nagy, Tineke Herremans, Marion Koopmans, György Szücs

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

Original languageEnglish
Pages (from-to)927-930
Number of pages4
JournalJournal of Medical Virology
Volume79
Issue number7
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Hepatitis E virus
Hungary
Hepatitis
Immunoglobulin G
Immunoglobulin M
Hepatitis E
Hepatitis A
Virus Diseases
Hepatitis C
Hepatitis B
Developed Countries
Western Blotting
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction
Antibodies

Keywords

  • Anti-HEV antibodies
  • Hepatitis E virus
  • HEV
  • Hungary
  • Non-A, non-B, non-C hepatitis
  • Sero-prevalence

ASJC Scopus subject areas

  • Virology

Cite this

Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. / Haagsman, Annika; Reuter, G.; Duizer, Erwin; Nagy, Gyuláné; Herremans, Tineke; Koopmans, Marion; Szücs, György.

In: Journal of Medical Virology, Vol. 79, No. 7, 07.2007, p. 927-930.

Research output: Contribution to journalArticle

Haagsman, A, Reuter, G, Duizer, E, Nagy, G, Herremans, T, Koopmans, M & Szücs, G 2007, 'Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary', Journal of Medical Virology, vol. 79, no. 7, pp. 927-930. https://doi.org/10.1002/jmv.20869
Haagsman, Annika ; Reuter, G. ; Duizer, Erwin ; Nagy, Gyuláné ; Herremans, Tineke ; Koopmans, Marion ; Szücs, György. / Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary. In: Journal of Medical Virology. 2007 ; Vol. 79, No. 7. pp. 927-930.
@article{f5552aa4028e4b8bb25dd119bc485066,
title = "Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary",
abstract = "Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5{\%} of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9{\%} had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1{\%} of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1{\%} of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.",
keywords = "Anti-HEV antibodies, Hepatitis E virus, HEV, Hungary, Non-A, non-B, non-C hepatitis, Sero-prevalence",
author = "Annika Haagsman and G. Reuter and Erwin Duizer and Gyul{\'a}n{\'e} Nagy and Tineke Herremans and Marion Koopmans and Gy{\"o}rgy Sz{\"u}cs",
year = "2007",
month = "7",
doi = "10.1002/jmv.20869",
language = "English",
volume = "79",
pages = "927--930",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary

AU - Haagsman, Annika

AU - Reuter, G.

AU - Duizer, Erwin

AU - Nagy, Gyuláné

AU - Herremans, Tineke

AU - Koopmans, Marion

AU - Szücs, György

PY - 2007/7

Y1 - 2007/7

N2 - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

AB - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.

KW - Anti-HEV antibodies

KW - Hepatitis E virus

KW - HEV

KW - Hungary

KW - Non-A, non-B, non-C hepatitis

KW - Sero-prevalence

UR - http://www.scopus.com/inward/record.url?scp=34249912113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249912113&partnerID=8YFLogxK

U2 - 10.1002/jmv.20869

DO - 10.1002/jmv.20869

M3 - Article

C2 - 17516521

AN - SCOPUS:34249912113

VL - 79

SP - 927

EP - 930

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 7

ER -