Serine proteases

J. Tóth, P. Medveczky, L. Szilágyi, L. Gráf

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Serine proteases are an ancient and large group of proteolytic enzymes that utilize a uniquely activated serine residue to catalyze peptide bond hydrolysis. Members of this protease family are highly diversified and are involved in numerous physiological and pathological processes. Their enzymatic activities are tightly regulated through transcription, translation, zymogen activation, autolysis, and interaction with natural inhibitors. In this chapter, the authors will begin with a brief description of the structure and function of serine proteases. Next, several members of this family of enzymes, including thrombin, plasmin, plasminogen activators, kallikreins, and human trypsin 4 are presented. These sections will discuss the genomic localization, gene structure, and regulation of expression of these proteases followed by the description of their enzymatic specificity and biological functions focusing on processes in the central nervous system (CNS).

Original languageEnglish
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function
PublisherSpringer US
Pages409-443
Number of pages35
ISBN (Print)9780387303468
DOIs
Publication statusPublished - 2007

Fingerprint

Serine Proteases
Peptide Hydrolases
Physiological Phenomena
Autolysis
Enzyme Precursors
Kallikreins
Plasminogen Activators
Fibrinolysin
Gene Expression Regulation
Neurology
Pathologic Processes
Transcription
Thrombin
Trypsin
Serine
Hydrolysis
Central Nervous System
Genes
Chemical activation
Peptides

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tóth, J., Medveczky, P., Szilágyi, L., & Gráf, L. (2007). Serine proteases. In Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function (pp. 409-443). Springer US. https://doi.org/10.1007/978-0-387-30379-6_14

Serine proteases. / Tóth, J.; Medveczky, P.; Szilágyi, L.; Gráf, L.

Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, 2007. p. 409-443.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tóth, J, Medveczky, P, Szilágyi, L & Gráf, L 2007, Serine proteases. in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, pp. 409-443. https://doi.org/10.1007/978-0-387-30379-6_14
Tóth J, Medveczky P, Szilágyi L, Gráf L. Serine proteases. In Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US. 2007. p. 409-443 https://doi.org/10.1007/978-0-387-30379-6_14
Tóth, J. ; Medveczky, P. ; Szilágyi, L. ; Gráf, L. / Serine proteases. Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, 2007. pp. 409-443
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