Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia

László Derzbach, Ádám Balogh, Géza Bokodi, B. Vásárhelyi, J. Rigó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN: P-selectin Thr715Pro and E-selectin Ser128Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume52
Issue number9
Publication statusPublished - Sep 2007

Fingerprint

P-Selectin
E-Selectin
Pre-Eclampsia
Genotype
Alleles
Regression Analysis
Eclampsia
Maternal Age
Hemolysis
Pregnant Women
Linear Models
Body Mass Index
Blood Platelets
Smoking
Hypertension
Pregnancy
Polymerase Chain Reaction
Liver
Enzymes
Population

Keywords

  • E-selectin
  • Genetic polymorphism
  • P-selectin
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia. / Derzbach, László; Balogh, Ádám; Bokodi, Géza; Vásárhelyi, B.; Rigó, J.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 52, No. 9, 09.2007, p. 815-818.

Research output: Contribution to journalArticle

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AU - Balogh, Ádám

AU - Bokodi, Géza

AU - Vásárhelyi, B.

AU - Rigó, J.

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N2 - OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN: P-selectin Thr715Pro and E-selectin Ser128Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.

AB - OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN: P-selectin Thr715Pro and E-selectin Ser128Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.

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