Ser128Arg E-selectin and Thr715Pro P-selectin polymorphisms and severe preeclampsia

László Derzbach, Ádám Balogh, Géza Bokodi, Barna Vásárhelyi, János Rigó

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4 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the association of functional E and P selectin polymorphisms with severe preeclampsia. STUDY DESIGN: P-selectin Thr715Pro and E-selectin Ser128Arg polymorphism were determined with the polymerase chain reaction in 126 women with severe preeclampsia and in 106 healthy pregnant women. Genotype distribution and allele prevalence of both groups were compared. Regression analysis was used to analyze the association between disease characteristics and genotype. RESULTS: Genotype distributions and the allele prevalence were similar in the tested populations. Furthermore, the genotypes investigated had no impact on the risk of eclampsia of the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Multiple linear regression analysis identified the P-selectin 715Pro allele as an independent determinant of the time of onset of hypertension (p = 0.034) along with maternal age, smoking and body mass index before pregnancy. CONCLUSION: The polymorphisms tested are not associated with the risk of severe preeclampsia.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume52
Issue number9
Publication statusPublished - Sep 1 2007

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Keywords

  • E-selectin
  • Genetic polymorphism
  • P-selectin
  • Preeclampsia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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