Sequential centrifugal layer chromatography (SCLC): A New technique for the isolation of natural compounds. Part 1: Description of the method and practical aspects

Sz Nyiredy, C. A.J. Erdelmeier, O. Sticher

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Sequential centrifugal layer chromatography (SCLC), a new preparative planar separation technique, combines the advantages of preparative centrifugal layer chromatography (CLC) and analytical, horizontal, anticircular, and sequential thin‐layer chromatography (TLC). In this on‐line preparative method, solvent delivery is locally and temporally variable, which means that the mobile phase can be brought onto the plate at any desired place. The SCLC apparatus operates in two modes: circular, with the help of centrifugal force in an inclined position, and anticircular, by means of capillary action in a horizontal position. These two operation modes can be combined and repeated as often as required, hence the separation space becomes practically unlimited. In this way the capacity and separation performance is significantly increased. In the present paper the apparatus and the method are described and some practical aspects are mentioned.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalJournal of High Resolution Chromatography
Issue number2
Publication statusPublished - Feb 1985



  • Anticircular development
  • Centrifugal layer chromatography, CLC
  • Circular development
  • Preparative planar chromatography, PPC
  • Sequential centrifugal layer chromatography, SCLC

ASJC Scopus subject areas

  • Chemical Engineering(all)

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