Sequential and domino Sonogashira coupling: Efficient tools for the synthesis of diarylalkynes

András Nagy, Zoltán Novák, András Kotschy

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38 Citations (Scopus)


The Sonogashira coupling reaction of aryl halides with a masked acetylene, leading to the formation of diarylethynes is reviewed. The process is either run in a sequential coupling-deprotection-coupling manner, or sometimes it is carried out in one-pot, a reaction we coined domino coupling. The procedures were also extended to the synthesis of compound libraries.

Original languageEnglish
Pages (from-to)4453-4461
Number of pages9
JournalJournal of Organometallic Chemistry
Issue number20 SPEC. ISS.
Publication statusPublished - Oct 10 2005



  • Cross-coupling
  • Diarylalkynes
  • Palladium
  • Sonogashira reaction

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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