Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis

H. Al-Awadhi, R. John, F. Al-Marzooqi, A. Vincze, F. Branicki, S. M. Karam

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Gastric cancer is the second leading cause of cancer related death worldwide. In the UAE, recent data show an increase in the number of patients with gastric cancer highlighting the need for greater understanding of its pathogenesis. Gastric cancer is generally believed to develop on a background of chronic atrophic gastritis which eventually leads to intestinal metaplasia, dysplasia and finally invasive carcinoma. Recently this multistep process of carcinogenesis has been challenged. Therefore, the aim of this study is to define alterations in antral mucosal biopsies and cancer tissues to investigate whether they could be used to assemble a tissue array supporting the multistep model of carcinogenesis. Gastric mucosal tissues were obtained from informed individuals undergoing endoscopy (for upper gastrointestinal symptoms) and gastrectomy (for adenocarcinoma) in Tawam Hospital. All tissues were processed for microscopic examination. Eighty nine antral biopsies were categorized as: normal (33%), mild superficial gastritis (34%) and severe atrophic gastritis (33%). About 5% of the latter exhibited evidence of intestinal metaplasia. Cancer tissues obtained from three patients were microscopically examined in three regions: safe resected margin, tumor edge and tumor center. Progressive changes in mucosal thickness, dysplasia and cellular transformation were observed, and when compared with alterations in biopsies, all appeared to represent a continuum of progression toward invasive adenocarcinoma. In conclusion, the tissue array presented in this study supports the multistep process of gastric carcinogenesis and will be helpful in examining the expression pattern of tumor markers or molecules that could help in the early detection of gastric cancer.

Original languageEnglish
Pages (from-to)1153-1164
Number of pages12
JournalHistology and Histopathology
Volume26
Issue number9
Publication statusPublished - Sep 2011

Fingerprint

Stomach
Carcinogenesis
Stomach Neoplasms
Biopsy
Atrophic Gastritis
Metaplasia
Neoplasms
Adenocarcinoma
Gastrointestinal Endoscopy
Gastritis
Gastrectomy
Tumor Biomarkers
Early Detection of Cancer
Mucous Membrane
Carcinoma
Antral

Keywords

  • Carcinogenesis
  • Gastric cancer
  • Gastritis
  • Intestinal metaplasia
  • Stomach

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Al-Awadhi, H., John, R., Al-Marzooqi, F., Vincze, A., Branicki, F., & Karam, S. M. (2011). Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis. Histology and Histopathology, 26(9), 1153-1164.

Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis. / Al-Awadhi, H.; John, R.; Al-Marzooqi, F.; Vincze, A.; Branicki, F.; Karam, S. M.

In: Histology and Histopathology, Vol. 26, No. 9, 09.2011, p. 1153-1164.

Research output: Contribution to journalArticle

Al-Awadhi, H, John, R, Al-Marzooqi, F, Vincze, A, Branicki, F & Karam, SM 2011, 'Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis', Histology and Histopathology, vol. 26, no. 9, pp. 1153-1164.
Al-Awadhi, H. ; John, R. ; Al-Marzooqi, F. ; Vincze, A. ; Branicki, F. ; Karam, S. M. / Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis. In: Histology and Histopathology. 2011 ; Vol. 26, No. 9. pp. 1153-1164.
@article{86c14954caaa45e6b44d8e2d43f423ad,
title = "Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis",
abstract = "Gastric cancer is the second leading cause of cancer related death worldwide. In the UAE, recent data show an increase in the number of patients with gastric cancer highlighting the need for greater understanding of its pathogenesis. Gastric cancer is generally believed to develop on a background of chronic atrophic gastritis which eventually leads to intestinal metaplasia, dysplasia and finally invasive carcinoma. Recently this multistep process of carcinogenesis has been challenged. Therefore, the aim of this study is to define alterations in antral mucosal biopsies and cancer tissues to investigate whether they could be used to assemble a tissue array supporting the multistep model of carcinogenesis. Gastric mucosal tissues were obtained from informed individuals undergoing endoscopy (for upper gastrointestinal symptoms) and gastrectomy (for adenocarcinoma) in Tawam Hospital. All tissues were processed for microscopic examination. Eighty nine antral biopsies were categorized as: normal (33{\%}), mild superficial gastritis (34{\%}) and severe atrophic gastritis (33{\%}). About 5{\%} of the latter exhibited evidence of intestinal metaplasia. Cancer tissues obtained from three patients were microscopically examined in three regions: safe resected margin, tumor edge and tumor center. Progressive changes in mucosal thickness, dysplasia and cellular transformation were observed, and when compared with alterations in biopsies, all appeared to represent a continuum of progression toward invasive adenocarcinoma. In conclusion, the tissue array presented in this study supports the multistep process of gastric carcinogenesis and will be helpful in examining the expression pattern of tumor markers or molecules that could help in the early detection of gastric cancer.",
keywords = "Carcinogenesis, Gastric cancer, Gastritis, Intestinal metaplasia, Stomach",
author = "H. Al-Awadhi and R. John and F. Al-Marzooqi and A. Vincze and F. Branicki and Karam, {S. M.}",
year = "2011",
month = "9",
language = "English",
volume = "26",
pages = "1153--1164",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Histology and Histopathology",
number = "9",

}

TY - JOUR

T1 - Sequential alterations in gastric biopsies and tumor tissues support the multistep process of carcinogenesis

AU - Al-Awadhi, H.

AU - John, R.

AU - Al-Marzooqi, F.

AU - Vincze, A.

AU - Branicki, F.

AU - Karam, S. M.

PY - 2011/9

Y1 - 2011/9

N2 - Gastric cancer is the second leading cause of cancer related death worldwide. In the UAE, recent data show an increase in the number of patients with gastric cancer highlighting the need for greater understanding of its pathogenesis. Gastric cancer is generally believed to develop on a background of chronic atrophic gastritis which eventually leads to intestinal metaplasia, dysplasia and finally invasive carcinoma. Recently this multistep process of carcinogenesis has been challenged. Therefore, the aim of this study is to define alterations in antral mucosal biopsies and cancer tissues to investigate whether they could be used to assemble a tissue array supporting the multistep model of carcinogenesis. Gastric mucosal tissues were obtained from informed individuals undergoing endoscopy (for upper gastrointestinal symptoms) and gastrectomy (for adenocarcinoma) in Tawam Hospital. All tissues were processed for microscopic examination. Eighty nine antral biopsies were categorized as: normal (33%), mild superficial gastritis (34%) and severe atrophic gastritis (33%). About 5% of the latter exhibited evidence of intestinal metaplasia. Cancer tissues obtained from three patients were microscopically examined in three regions: safe resected margin, tumor edge and tumor center. Progressive changes in mucosal thickness, dysplasia and cellular transformation were observed, and when compared with alterations in biopsies, all appeared to represent a continuum of progression toward invasive adenocarcinoma. In conclusion, the tissue array presented in this study supports the multistep process of gastric carcinogenesis and will be helpful in examining the expression pattern of tumor markers or molecules that could help in the early detection of gastric cancer.

AB - Gastric cancer is the second leading cause of cancer related death worldwide. In the UAE, recent data show an increase in the number of patients with gastric cancer highlighting the need for greater understanding of its pathogenesis. Gastric cancer is generally believed to develop on a background of chronic atrophic gastritis which eventually leads to intestinal metaplasia, dysplasia and finally invasive carcinoma. Recently this multistep process of carcinogenesis has been challenged. Therefore, the aim of this study is to define alterations in antral mucosal biopsies and cancer tissues to investigate whether they could be used to assemble a tissue array supporting the multistep model of carcinogenesis. Gastric mucosal tissues were obtained from informed individuals undergoing endoscopy (for upper gastrointestinal symptoms) and gastrectomy (for adenocarcinoma) in Tawam Hospital. All tissues were processed for microscopic examination. Eighty nine antral biopsies were categorized as: normal (33%), mild superficial gastritis (34%) and severe atrophic gastritis (33%). About 5% of the latter exhibited evidence of intestinal metaplasia. Cancer tissues obtained from three patients were microscopically examined in three regions: safe resected margin, tumor edge and tumor center. Progressive changes in mucosal thickness, dysplasia and cellular transformation were observed, and when compared with alterations in biopsies, all appeared to represent a continuum of progression toward invasive adenocarcinoma. In conclusion, the tissue array presented in this study supports the multistep process of gastric carcinogenesis and will be helpful in examining the expression pattern of tumor markers or molecules that could help in the early detection of gastric cancer.

KW - Carcinogenesis

KW - Gastric cancer

KW - Gastritis

KW - Intestinal metaplasia

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=80053198175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053198175&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 1153

EP - 1164

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

IS - 9

ER -