Sequence analysis of Schmallenberg virus genomes detected in Hungary

Eniko Fehér, Szilvia Marton, Ádám György Tóth, Krisztina Ursu, Kerstin Wernike, Martin Beer, Ádám Dán, Krisztián Bányai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Since its emergence near the German-Dutch border in 2011, Schmallenberg virus (SBV) has been identified in many European countries. In this study, we determined the complete coding sequence of seven Hungarian SBV genomes to expand our knowledge about the genetic diversity of circulating field strains. The samples originated from the first case, an aborted cattle fetus without malformation collected in 2012, and from the blood samples of six adult cattle in 2014. The Hungarian SBV sequences shared ≥99.3% nucleotide (nt) and ≥97.8% amino acid (aa) identity with each other, and ≥98.9 nt and ≥96.7% aa identity with reference strains. Although phylogenetic analyses showed low resolution in general, the M sequences of cattle and sheep origin SBV strains seemed to cluster on different branches. Both common and unique mutation sites were observed in different groups of sequences that might help understanding the evolution of emerging SBV strains.

Original languageEnglish
Pages (from-to)373-384
Number of pages12
JournalActa microbiologica et immunologica Hungarica
Volume64
Issue number4
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Cattle
  • Genome
  • Mutations
  • Schmallenberg virus
  • Sequence
  • Sheep

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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