Separation of oligomers of nonlphenylethylene oxide on a porous graphitized carbon column

Tibor Cserháti, Esther Forgács, Andrea Szilágyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The retention of nonylphenyl ethylene oxide oligomer surfactants was determined on a porous graphitized carbon (PGC) column using water-methanol mixtures as eluents. Linear correlations were calculated between the logarithm of the capacity factor (k') and the methanol concentration in the eluent. To test the validity of the hypothesis that in the case of homologous series of solutes the intercept and slope values are intercorrelated linear correlation was calculated between the two chromatographic parameters. To elucidate the role of the length of the polar ethylene oxide chain in the retention linear correlations were calculated between the chromatographic parameters and the number of ethylene oxide groups per molecule. Nonylphenyl ethylene oxide oligomers were well separated on the PGC column. Significant linear relationships were found between the corresponding chromatographic parameters indicating that the solutes behave as a homologous series of compounds. The retention of surfactants increased linearly with increasing number of ethylene oxide groups per molecule indicating hydrophilic interactions between the solutes and the surface of PGC support.

Original languageEnglish
Pages (from-to)1303-1307
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume15
Issue number9-10
DOIs
Publication statusPublished - Jun 1 1997

Keywords

  • Nonionic surfactants
  • Porous graphitized carbon column

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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