Separation of enantiomers by supercritical fluid extraction

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27 Citations (Scopus)


The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalJournal of Supercritical Fluids
Issue number1-3
Publication statusPublished - Jun 15 1998


  • Enantiomer
  • Experimental design
  • Racemate
  • Resolution
  • Supercritical extraction

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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