Separation of enantiomers by supercritical fluid extraction

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of the present study is to demonstrate the applicability of SFE for the separation of enantiomeric acid mixtures. (±)-cis- and (±)-trans-permetric acids were resolved with R-(+)-α-phenylethylamine and S-(+)-2-benzylaminobutan-1-ol, respectively. The effects of temperature and pressure on the quantity and quality of cis- and trans-acid resolution products are demonstrated. Partial resolutions of the acids were investigated in the range 100-200 bar and 33-47°C by designed experiments.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalJournal of Supercritical Fluids
Volume13
Issue number1-3
DOIs
Publication statusPublished - Jun 15 1998

Fingerprint

Supercritical fluids
Enantiomers
supercritical fluids
enantiomers
acids
Acids
Phenethylamines
products
Experiments
Temperature
temperature

Keywords

  • Enantiomer
  • Experimental design
  • Racemate
  • Resolution
  • Supercritical extraction

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Chemical Engineering(all)
  • Condensed Matter Physics

Cite this

Separation of enantiomers by supercritical fluid extraction. / Simándi, B.; Keszei, S.; Fogassy, E.; Kemény, S.; Sawinsky, J.

In: Journal of Supercritical Fluids, Vol. 13, No. 1-3, 15.06.1998, p. 331-336.

Research output: Contribution to journalArticle

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