Separation of enantiomers and control of elution order of β-lactams by GC using cyclodextrin-based Chiral stationary phases

Ke Huang, Daniel W. Armstrong, E. Forró, F. Fülöp, A. Péter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Enantiomers of 19 racemic β-lactams, with 3 and 4-position substitutions, were separated using gas chromatography. Excellent results were achieved on derivatized cyclodextrin-based GC chiral stationary phases (CSPs). All 19 compounds were baseline separated, most with high resolution factors. The Chiraldex G-TA was found to be the most powerful CSP with the broadest enantioselectivity, while Chiraldex B-DM produced the fastest separations for most of the compounds assayed. Results obtained in this work suggest that GC can serve as a potential method for the enantiomeric separation of sufficiently volatile solid β-lactams.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalChromatographia
Volume69
Issue number3-4
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Lactams
Enantiomers
Cyclodextrins
Enantioselectivity
Gas chromatography
Gas Chromatography
Substitution reactions

Keywords

  • β-Lactams
  • Cyclodextrin chiral stationary phase
  • Enantiomeric separation
  • Gas chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Separation of enantiomers and control of elution order of β-lactams by GC using cyclodextrin-based Chiral stationary phases. / Huang, Ke; Armstrong, Daniel W.; Forró, E.; Fülöp, F.; Péter, A.

In: Chromatographia, Vol. 69, No. 3-4, 02.2009, p. 331-337.

Research output: Contribution to journalArticle

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