1,4 - Benzodiazepin származékok elválasztása micelláris kapilláris elektroforézissel

Translated title of the contribution: Separation of 1,4-Benzodiazepine derivates by micellar elektrokinetic capillary chromatography

Hancu Gabriel, Gyéresi Árpád, Gáspár Attila

Research output: Contribution to journalArticle

Abstract

Our aim was to develop a capillary electrophoresis method for the separation of 1,4-benzodiazepine derivates. Benzodiazepines are hydrophobic substances, neutral from electrophoretic point of view, consequently the best method for their separation proved to be micellar elektrokinetic capillary chromatography (MECC). A fast and reliable method has been developed, for the 8 of the most frequently used benzodiazepine derivates, using a separation buffer composed of sodium tetraborate 25 mM (pH 9,3), SDS (50 mM) and methanol (at least 12%) as an organic modifier. Beside the separation we also studied the analytical condition for the separation (i.e. the effects of buffer concentration, modifier concentration and buffer pH on the separation).

Translated title of the contributionSeparation of 1,4-Benzodiazepine derivates by micellar elektrokinetic capillary chromatography
Original languageHungarian
Pages (from-to)176-179
Number of pages4
JournalActa pharmaceutica Hungarica
Volume77
Issue number3
Publication statusPublished - Oct 25 2007

ASJC Scopus subject areas

  • Pharmaceutical Science

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