1,4 - Benzodiazepin származékok elválasztása micelláris kapilláris elektroforézissel

Translated title of the contribution: Separation of 1,4-Benzodiazepine derivates by micellar elektrokinetic capillary chromatography

Hancu Gabriel, Gyéresi Árpád, A. Gáspár

Research output: Contribution to journalArticle

Abstract

Our aim was to develop a capillary electrophoresis method for the separation of 1,4-benzodiazepine derivates. Benzodiazepines are hydrophobic substances, neutral from electrophoretic point of view, consequently the best method for their separation proved to be micellar elektrokinetic capillary chromatography (MECC). A fast and reliable method has been developed, for the 8 of the most frequently used benzodiazepine derivates, using a separation buffer composed of sodium tetraborate 25 mM (pH 9,3), SDS (50 mM) and methanol (at least 12%) as an organic modifier. Beside the separation we also studied the analytical condition for the separation (i.e. the effects of buffer concentration, modifier concentration and buffer pH on the separation).

Original languageHungarian
Pages (from-to)176-179
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume77
Issue number3
Publication statusPublished - 2007

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Chromatography
Buffers
Benzodiazepines
Capillary Electrophoresis
Methanol
Bz-423
sodium borate

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

1,4 - Benzodiazepin származékok elválasztása micelláris kapilláris elektroforézissel. / Gabriel, Hancu; Árpád, Gyéresi; Gáspár, A.

In: Acta Pharmaceutica Hungarica, Vol. 77, No. 3, 2007, p. 176-179.

Research output: Contribution to journalArticle

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