Separate regulation of a membrane protein, gp130, present in receptor complex specific for interleukin‐6 and other functionally related cytokines

András Falus, Judit Biró, Éva Rákász, Thomas Brunner, Stephan Bischoff

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In addition to specific ligand binding elements, receptor assembly for interleukin(IL)‐6, oncostatin‐M, leukaemia inhibitory factor, ciliary neurotrophic factor and IL‐11 includes and additional unit, gp130. This molecule is a transmembrane glycoprotein of 130 kDa. In this paper, reviewing molecular, biochemical and functional data on gp130, we describe the dissimilar action of IL‐3 on the expression of the binding unit of the IL‐6 receptor and that of gp130. According to FACS studies, resting basophils express only IL‐6 receptors and no gp130 molecules on the plasma membranes. After incubation with IL‐3, the surface appearance and de novo transcription of gp130 was shown by FACS and mRNA polymerase chain reaction analysis.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalJournal of Molecular Recognition
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 1994

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Keywords

  • IL‐3
  • IL‐6 receptor
  • basophil
  • gp130

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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