Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis

Gábor Cserni, Simonetta Bianchi, Vania Vezzosi, Riccardo Arisio, Rita Bori, Johannes L. Peterse, Anna Sapino, Maria Drijkoningen, Janina Kulka, Vincenzo Eusebi, Maria Pia Foschini, Jean Pierre Bellocq, Cristi Marin, Sten Thorstenson, Isabel Amendoeira, Angelika Reiner-Concin, Thomas Decker

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12 Citations (Scopus)

Abstract

This study aimed at identifying factors related to sentinel lymph node (SLN) involvement in patients with tubular, cribriform, mucinous or papillary breast carcinoma and those related to non-SLN metastases if an SLN was positive. Multivariate analyses involved logistic and stepwise regressions. The SLNs harboured metastases in 85 of 572 cases, 78 of whom underwent axillary dissection; 19 presented non-SLN positive disease. Lack of lymphovascular invasion, a tumour size ≤10 mm and a single SLN removed were the factors predicting an SLN metastasis rate <10%, and patients with these features could be candidates for no surgical axillary staging. A positive SLN proportion of ≤50% and no lymphovascular invasion were associated with a <10% rate of non-SLN invasion; patients with a positive SLN and these features could be candidates for the omission of completion axillary dissection. The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively.

Original languageEnglish
Pages (from-to)1407-1414
Number of pages8
JournalEuropean Journal of Cancer
Volume43
Issue number9
DOIs
Publication statusPublished - Jun 1 2007

Keywords

  • Breast cancer
  • Isolated tumour cells
  • Micrometastasis
  • Mucinous carcinoma
  • Non-sentinel lymph node
  • Papillary carcinoma
  • Sentinel lymph node
  • Tubular carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Cserni, G., Bianchi, S., Vezzosi, V., Arisio, R., Bori, R., Peterse, J. L., Sapino, A., Drijkoningen, M., Kulka, J., Eusebi, V., Foschini, M. P., Bellocq, J. P., Marin, C., Thorstenson, S., Amendoeira, I., Reiner-Concin, A., & Decker, T. (2007). Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis. European Journal of Cancer, 43(9), 1407-1414. https://doi.org/10.1016/j.ejca.2007.04.004