Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors

József Lázár, Tamás Szabó, Rita Marincsák, László Kovács, Peter M. Blumberg, Tamás Bíró

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The vanilloid receptor (VR1) is a central integrator molecule of nociceptive stimuli. In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells. Our results clearly show that all neurotrophins sensitize the VR1 to capsaicin. Furthermore, using K252a, an inhibitor of tyrosine kinases, we present that actions of neurotrophins are mediated by the trk (A, B, C) receptors expressed in these cells. These data argue for the putative roles of neurotrophins in inducing inflammatory (thermal) hyperalgesia via VR1.

Original languageEnglish
Pages (from-to)153-163
Number of pages11
JournalLife Sciences
Volume75
Issue number2
DOIs
Publication statusPublished - May 28 2004

Keywords

  • Calcium
  • Heterologous expression system
  • Neurotrophins
  • Sensitization
  • Vanilloid receptor-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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