Sensitivity to catecholamines and histamine in the trained and in the untrained human organism and sensitivity changes during digestion

G. Pavlik, R. Frenkl

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16 Citations (Scopus)


Blood pressure and heart rate responses elicited by norepinephrine, epinephrine and histamine were compared before and after duodenal acidification in 27 trained and untrained young healthy men. Before acidification trained subjects showed a lower sensitivity to norepinephrine and histamine and a slightly lower one to epinephrine. In Order to explain these phenomena physical training was supposed to affect α, respectively β adrenergic responsivity in a dissimilar manner. This suggestion was confirmed by the isoproterenol studies, too. Duodenal acidification decreased the catecholamine-induced pressor responses. Depressor responses to histamine did not change in the untrained subjects, whereas they increased in the trained group. Thus, during digestion the histamine-induced depressor responses of trained subjects tended to approach that of untrained people.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number1
Publication statusPublished - Dec 1 1975



  • Adrenergic Responsivity
  • Circulatory Responses
  • Duodenal Acidification
  • Histamine
  • Physical Training

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health

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