Sensitivity of preincubated lymphocytes to suppressor regulation.

L. Kalmár, P. Gergely, K. Nékám, R. Gonzalez

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Abstract

DNA synthesis of human peripheral blood lymphocytes increases if Con A is added to the culture after 24 h preincubation at 37 degrees C. During preincubation the mitogen reactive lymphocytes lose their sensitivity to the suppressive effect of autologous mitomycin-treated mononuclear leukocytes, and of supernatants of autologous preincubated cells. The reactive lymphocytes preincubated at 4 degrees C retain their sensitivity to the suppressive effect of regulatory cells and their supernatants. It is assumed that the enhancement of mitogen response after preincubation at 37 degrees C is caused by a decrease of suppressor regulation of human lymphocytes. Prostaglandins may be regarded as one of the mediators of the suppression.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalActa medica Hungarica
Volume40
Issue number4
Publication statusPublished - Dec 1 1983

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kalmár, L., Gergely, P., Nékám, K., & Gonzalez, R. (1983). Sensitivity of preincubated lymphocytes to suppressor regulation. Acta medica Hungarica, 40(4), 195-202.