Sensitivity and specificity of Addenbrooke's Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson's disease

B. Kaszás, N. Kovács, I. Balás, J. Kállai, Z. Aschermann, Z. Kerekes, S. Komoly, F. Nagy, J. Janszky, T. Lucza, K. Karádi

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Introduction: Among the non-motor features of Parkinson's disease (PD), cognitive impairment is one of the most troublesome problems. Highly sensitive and specific screening instruments for detecting dementia in PD (PDD) are required in the clinical practice. Methods: In our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke's Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinson's disease patients without depression. By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD. Results: Best cut-off score for ACE to identify PDD was 80 points (sensitivity = 74.0%, specificity = 78.1%). For FAB the most optimal cut-off value was 12 points (sensitivity = 66.3%, specificity = 72.2%); whereas for MDRS it was 125 points (sensitivity = 89.8%, specificity = 98.3%). Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD. Conclusion: Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. Our results demonstrated that the specificity and sensitivity of MDRS was better than those of ACE, FAB and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalParkinsonism and Related Disorders
Volume18
Issue number5
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Parkinson Disease
Dementia
Sensitivity and Specificity
Hungary
Neuropsychological Tests
Movement Disorders
ROC Curve
Sample Size
Depression
Population
Cognitive Dysfunction

Keywords

  • Addenbrooke's Cognitive Examination
  • Frontal Assessment Battery
  • Mattis Dementia Rating Scale
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Sensitivity and specificity of Addenbrooke's Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson's disease. / Kaszás, B.; Kovács, N.; Balás, I.; Kállai, J.; Aschermann, Z.; Kerekes, Z.; Komoly, S.; Nagy, F.; Janszky, J.; Lucza, T.; Karádi, K.

In: Parkinsonism and Related Disorders, Vol. 18, No. 5, 06.2012, p. 553-556.

Research output: Contribution to journalArticle

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abstract = "Introduction: Among the non-motor features of Parkinson's disease (PD), cognitive impairment is one of the most troublesome problems. Highly sensitive and specific screening instruments for detecting dementia in PD (PDD) are required in the clinical practice. Methods: In our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke's Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinson's disease patients without depression. By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD. Results: Best cut-off score for ACE to identify PDD was 80 points (sensitivity = 74.0{\%}, specificity = 78.1{\%}). For FAB the most optimal cut-off value was 12 points (sensitivity = 66.3{\%}, specificity = 72.2{\%}); whereas for MDRS it was 125 points (sensitivity = 89.8{\%}, specificity = 98.3{\%}). Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD. Conclusion: Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. Our results demonstrated that the specificity and sensitivity of MDRS was better than those of ACE, FAB and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment.",
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AU - Kerekes, Z.

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