Sensitivity- and Gradient-Enhanced Heteronuclear Coupled/Decoupled HSQC-TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants

Katalin E. Kövér, Victor J. Hruby, Dušan Uhrín

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59 Citations (Scopus)


A pulsed field gradient version of the sensitivity-enhanced 2D HSQC-TOCSY experiment is proposed for measurement of long-range heteronuclear coupling constants. The coupling constants are obtained by computer-aided analysis of mixed-phase multiplets with and without the heteronuclear splitting. Generation of pure phase data is not required. Since large 1JXH and JHH couplings are used for coherence transfer, small nJXH can be measured accurately, which could be difficult to obtain from purely heteronuclear polarization transfer experiments.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Magnetic Resonance
Issue number2
Publication statusPublished - Dec 1997


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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