Sensitivity- and Gradient-Enhanced Heteronuclear Coupled/Decoupled HSQC-TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants

K. Kövér, Victor J. Hruby, Dušan Uhrín

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A pulsed field gradient version of the sensitivity-enhanced 2D HSQC-TOCSY experiment is proposed for measurement of long-range heteronuclear coupling constants. The coupling constants are obtained by computer-aided analysis of mixed-phase multiplets with and without the heteronuclear splitting. Generation of pure phase data is not required. Since large 1JXH and JHH couplings are used for coherence transfer, small nJXH can be measured accurately, which could be difficult to obtain from purely heteronuclear polarization transfer experiments.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Magnetic Resonance
Volume129
Issue number2
Publication statusPublished - Dec 1997

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Computer aided analysis
gradients
sensitivity
Experiments
Polarization
fine structure
polarization

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Sensitivity- and Gradient-Enhanced Heteronuclear Coupled/Decoupled HSQC-TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants. / Kövér, K.; Hruby, Victor J.; Uhrín, Dušan.

In: Journal of Magnetic Resonance, Vol. 129, No. 2, 12.1997, p. 125-129.

Research output: Contribution to journalArticle

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