Sensitivity analysis of bacterial chemotaxis models

Judit Danis, Tamás Turányi

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

Chemotaxis is the process, by which cells sense changes in their chemical environment and move towards more favorable conditions. This process is controlled by signaling pathways, which are relatively simple, but bear several important features of the ones of higher organisms. Sensitivity analysis of mathematical chemotaxis models of bacteria Escherichia coli and Bacillus subtilis was carried out and the most important parameters of the signal transduction cascades were determined. Global and local similarities of the sensitivity-time functions were found. Groups of parameters were identified in both models and changes of parameters within the same group can compensate each other to produce exactly the same response of the cell. This means that the parameter values in these models are not unique. On the other hand, this feature indicates a novel type of robustness of the signaling pathways.

Original languageEnglish
Pages (from-to)233-234
Number of pages2
JournalProcedia Computer Science
Volume7
DOIs
Publication statusPublished - Jan 1 2011
Event2nd European Future Technologies Conference and Exhibition 2011, FET 11 - Budapest, Hungary
Duration: May 4 2011May 6 2011

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Keywords

  • Chemotaxis
  • Computer modeling
  • Model identification
  • Signaling pathways
  • Systems biology

ASJC Scopus subject areas

  • Computer Science(all)

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