Self-stimulation in rats: Tip alignment influences the effectiveness of bipolar electrodes

I. Szabó, Peter M. Milner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Bipolar electrodes implanted in the posterior hypothalamus and ventral tegmentum of midbrain stimulate the reinforcement system more effectively when their tips are aligned in the medio-lateral direction then when these are aligned anteroposteriorly. This could in part explain the response variability in intracranial self-stimulation experiments. The current probably stimulates the tegmental cells and the lateral hypothalamic path neurons of the medial forebrain bundle with dendritic fields in the coronal plane, and anodal block prevents the sagittal propagation of rewarding impulses in the axons of these cells.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalBrain Research
Volume48
Issue numberC
DOIs
Publication statusPublished - Dec 24 1972

Fingerprint

Self Stimulation
Electrodes
Tegmentum Mesencephali
Posterior Hypothalamus
Medial Forebrain Bundle
Implanted Electrodes
Axons
Neurons
Direction compound
Reinforcement (Psychology)

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Self-stimulation in rats : Tip alignment influences the effectiveness of bipolar electrodes. / Szabó, I.; Milner, Peter M.

In: Brain Research, Vol. 48, No. C, 24.12.1972, p. 243-250.

Research output: Contribution to journalArticle

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