Self-defense of macrophages against oxidative injury: Fighting for their own survival

L. Virág, Rafael I. Jaén, Z. Regdon, Lisardo Boscá, Patricia Prieto

Research output: Contribution to journalReview article

Abstract

Activated macrophages play a central role in both the development and resolution of inflammation. These immune cells need to be functional in harmful conditions with high levels of reactive oxygen and nitrogen species that can damage their basic cell components, which may alter their metabolism. An excessive accumulation of these cell alterations drives macrophages inexorably to cell death, which has been associated to the development of several inflammatory diseases and even with aging in a process termed as “immunosenescence”. Macrophages, however, exhibit a prolonged survival in this hostile environment because they equip themselves with a complex network of protective mechanisms. Here we provide an overview of these self-defense mechanisms with special attention being paid to bioactive lipid mediators, NRF2 signaling and metabolic reprogramming.

Original languageEnglish
Article number101261
JournalRedox Biology
Volume26
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Macrophages
Wounds and Injuries
Reactive Nitrogen Species
Complex networks
Cell death
Cellular Structures
Metabolism
Reactive Oxygen Species
Cell Death
Aging of materials
Cells
Inflammation
Lipids

Keywords

  • Aging
  • Antioxidant
  • Apoptosis
  • Eicosanoids
  • FOXO
  • HO-1
  • Immunity
  • Inflammation
  • Macrophage
  • Metabolism
  • NRF2
  • Oxidative burst
  • PARP1
  • Parthanatos
  • Senescence
  • Specialized pro-resolving mediators

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Self-defense of macrophages against oxidative injury : Fighting for their own survival. / Virág, L.; Jaén, Rafael I.; Regdon, Z.; Boscá, Lisardo; Prieto, Patricia.

In: Redox Biology, Vol. 26, 101261, 01.09.2019.

Research output: Contribution to journalReview article

Virág, L. ; Jaén, Rafael I. ; Regdon, Z. ; Boscá, Lisardo ; Prieto, Patricia. / Self-defense of macrophages against oxidative injury : Fighting for their own survival. In: Redox Biology. 2019 ; Vol. 26.
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