Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors

Tímea Mosolygó, Annamária Kincses, Andrea Csonka, Ádám Szabó Tönki, Karolina Witek, Carmen Sanmartín, Małgorzata Anna Marć, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Enrique Domínguez-Álvarez, G. Spengler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli, and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogens.

Original languageEnglish
Article number1487
JournalMolecules
DOIs
Publication statusPublished - Apr 16 2019

Fingerprint

efflux
Multiple Drug Resistance
Methicillin-Resistant Staphylococcus aureus
inhibitors
Methicillin
Pumps
pumps
Anti-Bacterial Agents
Oxacillin
Quorum Sensing
Fluorometry
Enterococcus faecalis
Chlamydia trachomatis
Gram-Positive Bacteria
Microbial Sensitivity Tests
Staphylococcus aureus
Carbonyl compounds
Public Health
Public health
Pathogens

Keywords

  • AcrAB-TolC efflux pump
  • Chlamydia trachomatis D
  • Escherichia coli K-12 AG100
  • Selenocompounds
  • Selenoesters
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Mosolygó, T., Kincses, A., Csonka, A., Tönki, Á. S., Witek, K., Sanmartín, C., ... Spengler, G. (2019). Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors. Molecules, [1487]. https://doi.org/10.3390/molecules24081487

Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors. / Mosolygó, Tímea; Kincses, Annamária; Csonka, Andrea; Tönki, Ádám Szabó; Witek, Karolina; Sanmartín, Carmen; Marć, Małgorzata Anna; Handzlik, Jadwiga; Kieć-Kononowicz, Katarzyna; Domínguez-Álvarez, Enrique; Spengler, G.

In: Molecules, 16.04.2019.

Research output: Contribution to journalArticle

Mosolygó, T, Kincses, A, Csonka, A, Tönki, ÁS, Witek, K, Sanmartín, C, Marć, MA, Handzlik, J, Kieć-Kononowicz, K, Domínguez-Álvarez, E & Spengler, G 2019, 'Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors', Molecules. https://doi.org/10.3390/molecules24081487
Mosolygó T, Kincses A, Csonka A, Tönki ÁS, Witek K, Sanmartín C et al. Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors. Molecules. 2019 Apr 16. 1487. https://doi.org/10.3390/molecules24081487
Mosolygó, Tímea ; Kincses, Annamária ; Csonka, Andrea ; Tönki, Ádám Szabó ; Witek, Karolina ; Sanmartín, Carmen ; Marć, Małgorzata Anna ; Handzlik, Jadwiga ; Kieć-Kononowicz, Katarzyna ; Domínguez-Álvarez, Enrique ; Spengler, G. / Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors. In: Molecules. 2019.
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