Selenium levels in men with liver disease in Hungary

Beáta éva Petrovski, Vera Pataki, Tibor Jenei, R. Ádány, Z. Vokó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Project: We studied the relationship between selenium (Se) levels and chronic liver disease (CLD) severity and the association between socioeconomic and lifestyle factors and serum Se levels. Procedure: We performed a case-control study in Hungarian men, examining 281 patients with CLD and 778 controls. Liver function was evaluated using biochemical markers, and liver disease was verified with physical examination and blood tests. Linear regression analysis was performed to study the association of serum Se level with biochemical markers in cases and controls. In control participants we examined the relationship between Se levels and age, financial status, education, alcohol consumption, cigarette smoking, type of fat used for cooking and body mass index. Results: Serum Se levels were lower in cases (median 0.87 μmol/L (IQR: 0.77-1.03)) than in controls (median 1.08 μmol/L (IQR: 0.97-1.19)). In controls, increases in bilirubin and glutamic-oxaloacetic transaminase (GOT) were associated with decreases in Se levels. In patients with CLD, a statistically significant relationship was found between serum Se and the GOT/GPT ratio, albumin and bilirubin. Younger, better-educated controls had significantly higher, and regular smokers and heavy drinkers had significantly lower Se levels. The use of vegetable oil/fat was also associated with higher Se levels. Se level was associated with the severity of liver injury in people even in patients who did not exhibit signs and symptoms of CLD. Conclusions: Serum Se level is strongly associated with the severity of liver damage in people with CLD from the early stage on.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalJournal of Trace Elements in Medicine and Biology
Volume26
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Hungary
Selenium
Liver
Liver Diseases
Chronic Disease
Aspartate Aminotransferases
Serum
Bilirubin
Biomarkers
Fats
Plant Oils
Cooking
Hematologic Tests
Linear regression
Regression analysis
Tobacco Products
Alcohol Drinking
Signs and Symptoms
Physical Examination
Case-Control Studies

Keywords

  • Chronic liver disease
  • Hungary
  • Selenium

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

Cite this

Selenium levels in men with liver disease in Hungary. / Petrovski, Beáta éva; Pataki, Vera; Jenei, Tibor; Ádány, R.; Vokó, Z.

In: Journal of Trace Elements in Medicine and Biology, Vol. 26, No. 1, 2012, p. 31-35.

Research output: Contribution to journalArticle

Petrovski, Beáta éva ; Pataki, Vera ; Jenei, Tibor ; Ádány, R. ; Vokó, Z. / Selenium levels in men with liver disease in Hungary. In: Journal of Trace Elements in Medicine and Biology. 2012 ; Vol. 26, No. 1. pp. 31-35.
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