Selectivity of methylation of some new [1,2,3]triazolo[4,5-d]pyridazines and structure elucidation by 1H-15H NMR spectroscopy

A. Csámpai, Péter Kövér, G. Hajós, Z. Riedl

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Alkylation of some selected [1,2,3]triazolo[4,5-d]pyridazines having five or more nitrogen atoms capable for alkylation was investigated. Pyridyl derivatives substituted also on the [1,2,3]triazole ring gave quaternary pyridinium salts, whereas in the case of the analogues compounds unsubstituted at the triazole moiety, the alkylation of the triazole ring was also observed. Unambiguous structure elucidation was provided by 1H-15N HMBC experiments which also allowed the assignment of the 15N NMR shifts.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of Molecular Structure
Volume616
Issue number1-3
DOIs
Publication statusPublished - Oct 1 2002

Fingerprint

Pyridazines
methylation
Triazoles
Methylation
alkylation
Alkylation
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
selectivity
nuclear magnetic resonance
spectroscopy
rings
nitrogen atoms
Nitrogen
Salts
Nuclear magnetic resonance
analogs
salts
Derivatives
Atoms

Keywords

  • 2D NMR
  • N NMR spectroscopy
  • Fused pyridazines
  • Methylation
  • Selectivity

ASJC Scopus subject areas

  • Structural Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Atomic and Molecular Physics, and Optics

Cite this

@article{ccd2dbdc98c24453b6f7fe12756495a1,
title = "Selectivity of methylation of some new [1,2,3]triazolo[4,5-d]pyridazines and structure elucidation by 1H-15H NMR spectroscopy",
abstract = "Alkylation of some selected [1,2,3]triazolo[4,5-d]pyridazines having five or more nitrogen atoms capable for alkylation was investigated. Pyridyl derivatives substituted also on the [1,2,3]triazole ring gave quaternary pyridinium salts, whereas in the case of the analogues compounds unsubstituted at the triazole moiety, the alkylation of the triazole ring was also observed. Unambiguous structure elucidation was provided by 1H-15N HMBC experiments which also allowed the assignment of the 15N NMR shifts.",
keywords = "2D NMR, N NMR spectroscopy, Fused pyridazines, Methylation, Selectivity",
author = "A. Cs{\'a}mpai and P{\'e}ter K{\"o}v{\'e}r and G. Haj{\'o}s and Z. Riedl",
year = "2002",
month = "10",
day = "1",
doi = "10.1016/S0022-2860(02)00320-4",
language = "English",
volume = "616",
pages = "73--78",
journal = "Journal of Molecular Structure",
issn = "0022-2860",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Selectivity of methylation of some new [1,2,3]triazolo[4,5-d]pyridazines and structure elucidation by 1H-15H NMR spectroscopy

AU - Csámpai, A.

AU - Kövér, Péter

AU - Hajós, G.

AU - Riedl, Z.

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Alkylation of some selected [1,2,3]triazolo[4,5-d]pyridazines having five or more nitrogen atoms capable for alkylation was investigated. Pyridyl derivatives substituted also on the [1,2,3]triazole ring gave quaternary pyridinium salts, whereas in the case of the analogues compounds unsubstituted at the triazole moiety, the alkylation of the triazole ring was also observed. Unambiguous structure elucidation was provided by 1H-15N HMBC experiments which also allowed the assignment of the 15N NMR shifts.

AB - Alkylation of some selected [1,2,3]triazolo[4,5-d]pyridazines having five or more nitrogen atoms capable for alkylation was investigated. Pyridyl derivatives substituted also on the [1,2,3]triazole ring gave quaternary pyridinium salts, whereas in the case of the analogues compounds unsubstituted at the triazole moiety, the alkylation of the triazole ring was also observed. Unambiguous structure elucidation was provided by 1H-15N HMBC experiments which also allowed the assignment of the 15N NMR shifts.

KW - 2D NMR

KW - N NMR spectroscopy

KW - Fused pyridazines

KW - Methylation

KW - Selectivity

UR - http://www.scopus.com/inward/record.url?scp=0036784551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036784551&partnerID=8YFLogxK

U2 - 10.1016/S0022-2860(02)00320-4

DO - 10.1016/S0022-2860(02)00320-4

M3 - Article

AN - SCOPUS:0036784551

VL - 616

SP - 73

EP - 78

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

SN - 0022-2860

IS - 1-3

ER -