Selectively monomodified cyclodextrins, synthetic strategies

Shengping Tian, Henghu Zhu, Peter Forgo, Valerian T. D'Souza

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Abstract

Monomodifications of cyclodextrins to give selectively 2-, 3-, or 6- substituted product is a challenging task because of the number of hydroxyl groups that can potentially react with the incoming reagent. The principles and the methods involved in manipulations of the differences in the chemistry of these hydroxyl groups to control the outcome of an electrophilic reaction with them to produce monoalkylated (ether-linkaged) cyclodextrin derivatives are discussed and illustrated.

Original languageEnglish
Pages (from-to)2624-2630
Number of pages7
JournalJournal of Organic Chemistry
Volume65
Issue number9
DOIs
Publication statusPublished - May 5 2000

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ASJC Scopus subject areas

  • Organic Chemistry

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