Selective voltammetric determination of electroactive neuromodulating species in biological samples using iron(II) phthalocyanine modified multi-wall carbon nanotubes paste electrode

Daniela Patrascu, Iulia David, Vasile David, Constantin Mihailciuc, Ioan Stamatin, Jean Ciurea, Livia Nagy, Géza Nagy, Anton Alexandru Ciucu

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29 Citations (Scopus)


Iron(II) phthalocyanine (FePc) modified multi-wall carbon nanotubes paste electrodes (MWCNTPEs) were used as voltammetric sensors to selectively detect dopamine (DA) in the presence of serotonin (5-HT). The electrochemical behavior of DA at the new modified electrode was investigated using CV. The enhanced current response of DA indicates that FePc modification of the MWCNTPE surface results in a high catalytic activity for the redox reaction of DA. Differential pulse voltammetry was applied in detection of DA and 5-HT at FePc-MWCNTPE. The method parameters were optimized. Detection limit of 2.05 × 10 -7 M was obtained for DA by using the electrocatalytic oxidation signal corresponding to the FeII/FeIII redox process. The separation between the peak potentials of DA and 5-HT is 170 mV which is large enough for the simultaneously, selective determination of the two chemical species in their mixtures. There was no electrochemical response for ascorbic acid (AA) added in the sample. The monoamine neurotransmitter measuring method has been tested in analyzing deproteinized serum samples.

Original languageEnglish
Pages (from-to)731-736
Number of pages6
JournalSensors and Actuators, B: Chemical
Issue number2
Publication statusPublished - Aug 1 2011



  • Differential pulse voltammetry
  • Dopamine
  • Iron(II) phthalocyanine
  • Serotonin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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