Selective sympathetic denervation induced by 6 hydroxy dopamine in the small intestine

E. Fehér, J. Vajda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The structure of the nerve fibers in the intact and neurally isolated intestine of the cat was studied after 6-OHDA treatment by fluorescence and electron microscopy. A gradual disappearance of green fluorescence in the monoaminergic fibers was observed. Degeneration of nerve fibers containing 30-60 nm agranular and 30-60 nm dense- core (granular) vesicles could be seen in all layers of the small intestine. Sporadically, degeneration of the presynaptic elements occurred also in the synapses of myenteric ganglia. A large number of degenerating fibers could be observed in close relation to blood vessels. These were thought to be monoaminergic because 6-OHDA selectively affected their terminals. In the chronically isolated small intestine degenerated nerve processes could not be observed following 6-OHDA treatment. It is concluded that the intrinsic nerve elements do not contain monoamines. Accordingly, the previously observed yellow fluorescence of the nerve elements of the isolated small intestine might be due to some other kind of neurotransmitter, possibly tryptamine.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalActa Morphologica Academiae Scientiarum Hungaricae
Volume24
Issue number1-2
Publication statusPublished - 1976

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Sympathectomy
Oxidopamine
Small Intestine
Dopamine
Nerve Fibers
Fluorescence
Secretory Vesicles
Fluorescence Microscopy
Ganglia
Synapses
Intestines
Neurotransmitter Agents
Blood Vessels
Electron Microscopy
Cats

ASJC Scopus subject areas

  • Anatomy

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Selective sympathetic denervation induced by 6 hydroxy dopamine in the small intestine. / Fehér, E.; Vajda, J.

In: Acta Morphologica Academiae Scientiarum Hungaricae, Vol. 24, No. 1-2, 1976, p. 121-128.

Research output: Contribution to journalArticle

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