Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells

János Brunner, Jeanne Ster, Susan Van-Weert, Tibor Andrási, Máté Neubrandt, Corrado Corti, Mauro Corsi, Francesco Ferraguti, Urs Gerber, J. Szabadics

Research output: Contribution to journalArticle

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Abstract

Group II metabotropic glutamate receptors (mGlu-IIs) modulate hippocampal information processing through several presynaptic actions. We describe a novel postsynaptic inhibitory mechanism mediated by the mGlu2 subtype that activates an inwardly rectifying potassium conductance in the dendrites ofDGgranule cells of rats and mice. Data from glutamate-uncaging experiments and simulations indicate that mGlu2-activated potassium conductance uniformly reduces the peak amplitude of synaptic inputs arriving in the distal two-thirds of dendrites, with only minor effects on proximal inputs. This unique shunting profile is consistent with a peak expression of the mGlu2-activated conductance at the transition between the proximal and middle third of the dendrites. Further simulations under various physiologically relevant conditions showed that when a shunting conductance was activated in the proximal third of a single dendrite, it effectively modulated input to this specific branch while leaving inputs in neighboring dendrites relatively unaffected. Therefore, the restricted expression of the mGlu2-activated potassium conductance in the proximal third of DG granule cell dendrites represents an optimal localization for achieving the opposing biophysical requirements for uniform yet selective modulation of individual dendritic branches.

Original languageEnglish
Pages (from-to)7285-7298
Number of pages14
JournalJournal of Neuroscience
Volume33
Issue number17
DOIs
Publication statusPublished - Apr 24 2013

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Dentate Gyrus
Dendrites
Potassium
Metabotropic Glutamate Receptors
Automatic Data Processing
Glutamic Acid

ASJC Scopus subject areas

  • Neuroscience(all)

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Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells. / Brunner, János; Ster, Jeanne; Van-Weert, Susan; Andrási, Tibor; Neubrandt, Máté; Corti, Corrado; Corsi, Mauro; Ferraguti, Francesco; Gerber, Urs; Szabadics, J.

In: Journal of Neuroscience, Vol. 33, No. 17, 24.04.2013, p. 7285-7298.

Research output: Contribution to journalArticle

Brunner, J, Ster, J, Van-Weert, S, Andrási, T, Neubrandt, M, Corti, C, Corsi, M, Ferraguti, F, Gerber, U & Szabadics, J 2013, 'Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells', Journal of Neuroscience, vol. 33, no. 17, pp. 7285-7298. https://doi.org/10.1523/JNEUROSCI.4537-12.2013
Brunner, János ; Ster, Jeanne ; Van-Weert, Susan ; Andrási, Tibor ; Neubrandt, Máté ; Corti, Corrado ; Corsi, Mauro ; Ferraguti, Francesco ; Gerber, Urs ; Szabadics, J. / Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 17. pp. 7285-7298.
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