Selective removal of 2,2,2-trichloroethyl- and 2,2,2- trichloroethoxycarbonyl protecting groups with Zn-N-methylimidazole in the presence of reducible and acid-sensitive functionalities

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Abstract

Activated zinc dust in the presence of N-methylimidazole in ethyl acetate or acetone at reflux or room temperature removes 2,2,2-trichloroethyl- and 2,2,2-trichloroethoxycarbonyl protecting groups while azido-, nitro-, chloro-, phenacyl-, and tert-butyl ester functionalities as well as double bonds remain intact.

Original languageEnglish
Pages (from-to)9095-9097
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number49
DOIs
Publication statusPublished - Nov 29 2004

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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