Selective nitrile oxide dipolar cycloaddition for the synthesis of highly functionalized β-aminocyclohexanecarboxylate stereoisomers

Melinda Nonn, L. Kiss, Reijo Sillanpää, F. Fülöp

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthesized from a bicyclic β-lactam by successive regioselective iodolactonization, stereo- and regioselective nitrile oxide cycloaddition, lactone ring-opening and isoxazoline ring-opening.

Original languageEnglish
Pages (from-to)9942-9948
Number of pages7
JournalTetrahedron
Volume68
Issue number48
DOIs
Publication statusPublished - Dec 2 2012

Fingerprint

Lactams
Nitriles
Stereoisomerism
Cycloaddition
Cycloaddition Reaction
Lactones
Oxides

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Selective nitrile oxide dipolar cycloaddition for the synthesis of highly functionalized β-aminocyclohexanecarboxylate stereoisomers. / Nonn, Melinda; Kiss, L.; Sillanpää, Reijo; Fülöp, F.

In: Tetrahedron, Vol. 68, No. 48, 02.12.2012, p. 9942-9948.

Research output: Contribution to journalArticle

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