Selective inhibition of the 'B form' of monoamine oxidase

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17 Citations (Scopus)

Abstract

Deprenyl (phenyl-isopropyl-methyl-propinylamine) is a potent inhibitor of monoamine oxidase (MAO) and like the acetylenic type of inhibitors it induces irreversible inhibition of the enzyme. Its levorotatory isomer is a more potent inhibitor than the dextrorotatory one. Deprenyl elevates the concentration of 3H-noradrenaline (3H-NA) in the synaptosomal fraction of rat heart homogenate while pargyline, probably due to its releasing effect, decreases 3H-NA content in the same fraction. Deprenyl is a selective inhibitor of the 'B form' of MAO, which preferentially oxidizes β-phenylethylamine as substrate.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalPolish Journal of Pharmacology and Pharmacy
Volume29
Issue number3
Publication statusPublished - 1977

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Selegiline
Monoamine Oxidase
Norepinephrine
Pargyline
Phenethylamines
Monoamine Oxidase Inhibitors
Enzymes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Selective inhibition of the 'B form' of monoamine oxidase. / Magyar, K.; Knoll, J.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 29, No. 3, 1977, p. 233-246.

Research output: Contribution to journalArticle

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